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    CG6763 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6763provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039069
    Locus tag
    Dmel_CG6763
    See related
    AllianceGenome:FB:FBgn0039069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6763
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic Malpighian tubule. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6763 in Genome Data Viewer
    Location:
    94E9-94E9; 3-78 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23284002..23286041)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19109724..19111763)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Peroxin 11c Neighboring gene oo18 RNA-binding protein Neighboring gene Cell division cycle 16 Neighboring gene wampa Neighboring gene big bubble 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    2. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6763-PA
    CG6763-PB
    NP_001262871.1
    NP_651138.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23284002..23286041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142881.3 → NP_651138.1  uncharacterized protein Dmel_CG6763, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCN5
      Related
      FBpp0083770
      Conserved Domains (2) summary
      cd04280
      Location:119 → 300
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:116 → 304
      Astacin; Astacin (Peptidase family M12A)

    2. NM_001275942.1 → NP_001262871.1  uncharacterized protein Dmel_CG6763, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCN5
      Conserved Domains (2) summary
      cd04280
      Location:119 → 300
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:116 → 304
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCN5 Q9VCN5

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