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    Zip89B Zinc/iron regulated transporter-related protein 89B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zip89Bprovided by FlyBase
    Official Full Name
    Zinc/iron regulated transporter-related protein 89Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038412
    Locus tag
    Dmel_CG6898
    See related
    AllianceGenome:FB:FBgn0038412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6898; CG6898; Dmel\CG6898; dZip3; dZip89B; dZIP89B; Zip3; ZIP3; ZIP89B
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Involved in detoxification of zinc ion. Located in apical plasma membrane. Is expressed in embryonic midgut constriction 1; embryonic/larval Malpighian tubule Type II cell; gastric caecum; gland; and gut section. Orthologous to human SLC39A2 (solute carrier family 39 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zip89B in Genome Data Viewer
    Location:
    89B12-89B12; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16305758..16308700)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12131480..12134422)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mst89B Neighboring gene Maternal transcript 89Ba Neighboring gene gilgamesh Neighboring gene transfer RNA:Phenylalanine-GAA 1-8 Neighboring gene Sulfated Neighboring gene transfer RNA:Valine-AAC 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. Gutiérrez L, et al. FEBS Lett, 2010 Jul 2. PMID 20493851
    2. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Richards CD, et al. Int J Biochem Cell Biol, 2015 Dec. PMID 26545796
    3. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. Lye JC, et al. J Biol Inorg Chem, 2013 Mar. PMID 23322169
    4. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Wang J, et al. Metallomics, 2014 Nov. PMID 25209718
    5. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Dechen K, et al. Int J Biochem Cell Biol, 2015 Mar. PMID 25562517

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dZIP89B works in concert with the closely related dZIP42C.1 and 2 to ensure optimal zinc absorption under a range of dietary conditions.
      Title: A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc/iron regulated transporter-related protein 89B
    Names
    CG6898-PA
    Zinc-iron transporter
    Zinc/iron regulated transporter-related protein 3
    Zinc/iron transporter-related protein 3
    Zip89B-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16305758..16308700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080499.3 → NP_536747.2  Zinc/iron regulated transporter-related protein 89B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536747.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZF0, Q9VEX1
      Related
      FBpp0082720
      Conserved Domains (1) summary
      pfam02535
      Location:53 → 406
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZF0 Q8SZF0
    Q9GRW9 Q9GRW9
    Q9VEX1 Q9VEX1

    Gene LinkOut

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