Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnq3provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily Q, member 3provided by MGI
Primary source: MGI:MGI:1336181
See related: Ensembl:ENSMUSG00000056258 AllianceGenome:MGI:1336181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables calmodulin binding activity; potassium channel activity; and voltage-gated monoatomic ion channel activity. Acts upstream of or within several processes, including chemical synaptic transmission; establishment of protein localization; and nervous system development. Located in axon initial segment; node of Ranvier; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in cell surface. Is expressed in several structures, including central nervous system; midgut; retina; and rib. Used to study benign neonatal seizures. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 5.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 29.16 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (65858223..66158485, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (65986374..66286636, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.
Title: KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.
CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance.
Title: CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance.
Autism-associated mutations in KV7 channels induce gating pore current.
Title: Autism-associated mutations in K(V)7 channels induce gating pore current.
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Title: The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Title: Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
decreases in interneuron KCNQ2/3 activity remodels excitatory networks, providing a new function for these channels.
Title: Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission.
USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
KCNQ3 plays an essential role in maintaining the slow afterhyperpolarization under low phosphatidylinositol diphosphate conditions.
Title: The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels.
Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3-/- and in Kcnq2+/-/Kcnq3-/- Mutant Mice.
Title: KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.
Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.
Title: Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnq3 (e-PCR), detects polymorphism
- UniSTS:143685

D15Mit233 (e-PCR), detects polymorphism
- UniSTS:127605

Kcnq3 (e-PCR), detects polymorphism
- UniSTS:259499

14.MMHAP76FRE8.seq (e-PCR)
- UniSTS:186314

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated monoatomic ion channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within action potential initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within action potential initiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within action potential initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ammonium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inhibitory chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within psychomotor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of action potential firing threshold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to auditory stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within substantia propria of cornea development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon initial segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon initial segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 3

Names: KQT-like 3; potassium channel subunit alpha KvLQT3; voltage-gated potassium channel subunit Kv7.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152923.3 → NP_690887.2 potassium voltage-gated channel subfamily KQT member 3

See identical proteins and their annotated locations for NP_690887.2

Status: VALIDATED

Source sequence(s)

AC091276, AC102633, AC110897

Consensus CDS

CCDS49619.1

UniProtKB/Swiss-Prot

E9QJY5, Q8K3F6

UniProtKB/TrEMBL

Q14B66

Related

ENSMUSP00000063380.7, ENSMUST00000070256.9

Conserved Domains (4) summary

pfam00520
Location:140 → 364

Ion_trans; Ion transport protein

pfam03520
Location:453 → 657

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:270 → 354

Ion_trans_2; Ion channel

pfam11956
Location:781 → 867

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

65858223..66158485 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159073.1 → XP_036014966.1 potassium voltage-gated channel subfamily KQT member 3 isoform X1

Conserved Domains (2) summary

pfam03520
Location:36 → 235

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:355 → 451

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3