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    Esyt3 extended synaptotagmin-like protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 272636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esyt3provided by MGI
    Official Full Name
    extended synaptotagmin-like protein 3provided by MGI
    Primary source
    MGI:MGI:1098699
    See related
    Ensembl:ENSMUSG00000037681 AllianceGenome:MGI:1098699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam62c; mKIAA4186; D930024E11; D9Ertd280e
    Summary
    Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; immune system; and nervous system. Orthologous to human ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 7.8), genital fat pad adult (RPKM 4.7) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Esyt3 in Genome Data Viewer
    Location:
    9 E3.3; 9 51.54 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99192016..99242210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99309963..99360159, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene muscle and microspikes RAS Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. Zhang Y, et al. Proc Natl Acad Sci U S A, 2020 Aug 18. PMID 32747560, Free PMC Article
    2. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. Sclip A, et al. PLoS One, 2016. PMID 27348751, Free PMC Article
    3. Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Herdman C, et al. Cell Cycle, 2014. PMID 25486202, Free PMC Article
    4. Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1. Ma Y, et al. Cell Rep, 2023 Jul 25. PMID 37393619, Free PMC Article
    5. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Tremblay MG, et al. Cell Cycle, 2016 Sep. PMID 27399837, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.
      Title: Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4186

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extended synaptotagmin-3
    Names
    E-Syt3
    family with sequence similarity 62 (C2 domain containing), member C
    family with sequence similarity 62, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177775.3 → NP_808443.2  extended synaptotagmin-3

      See identical proteins and their annotated locations for NP_808443.2

      Status: VALIDATED

      Source sequence(s)
      AK086367, AK142948, BY754935
      Consensus CDS
      CCDS40739.1
      UniProtKB/Swiss-Prot
      Q0VF61, Q5DTI8, Q8C3B9
      Related
      ENSMUSP00000038757.7, ENSMUST00000042158.13
      Conserved Domains (4) summary
      cd04030
      Location:759 → 884
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:449 → 572
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:310 → 428
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:118 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      99192016..99242210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511221.5 → XP_006511284.1  extended synaptotagmin-3 isoform X1

      See identical proteins and their annotated locations for XP_006511284.1

      UniProtKB/Swiss-Prot
      Q0VF61, Q5DTI8, Q8C3B9
      Conserved Domains (4) summary
      cd04030
      Location:759 → 884
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:449 → 572
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:310 → 428
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:118 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    2. XM_011242752.3 → XP_011241054.1  extended synaptotagmin-3 isoform X2

      Conserved Domains (4) summary
      cd04030
      Location:495 → 620
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:185 → 308
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:46 → 164
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:1 → 30
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTI8.2 GenPept UniProtKB/Swiss-Prot:Q5DTI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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