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    Serinc3 serine incorporator 3 [ Mus musculus (house mouse) ]

    Gene ID: 26943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serinc3provided by MGI
    Official Full Name
    serine incorporator 3provided by MGI
    Primary source
    MGI:MGI:1349457
    See related
    Ensembl:ENSMUSG00000017707 AllianceGenome:MGI:1349457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tde1; AIGP1; TMS-1; DIFF33
    Summary
    Acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including adrenal medulla; craniocervical region bone; ganglia; liver lobe; and thymus primordium. Orthologous to human SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 233.6), ovary adult (RPKM 192.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serinc3 in Genome Data Viewer
    Location:
    2 H3; 2 84.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163466577..163487767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163623273..163645149, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2652 Neighboring gene STARR-seq mESC enhancer starr_06312 Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9538 Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of a novel cDNA which is overexpressed in testicular tumors from polyomavirus large T-antigen transgenic mice. Lebel M, et al. DNA Seq, 1994. PMID 7894057
    2. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. Bossolasco M, et al. Mol Carcinog, 1999 Nov. PMID 10559794
    3. Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress. Aoki S, et al. J Neurosci, 2002 Dec 15. PMID 12486168, Free PMC Article
    4. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Bossolasco M, et al. Oncogene, 2006 Aug 3. PMID 16547497
    5. SERINC5 Potently Restricts Retrovirus Infection In Vivo. Timilsina U, et al. mBio, 2020 Jul 14. PMID 32665269, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TDE1 inhibits apoptosis and stimulates tumorigenesis
      Title: Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.
    2. results suggest that AIGP1 gene activation and protein accumulation in the Golgi complex in response to axotomy-induced ER-Golgi stress may contribute to signaling during programmed cell death in damaged neurons [AIGP1]
      Title: Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in detection of virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine incorporator 3
    Names
    AIGP-1
    axotomy-induced glyco/Golgi protein 1
    axotomy-induced glycoprotein 1
    membrane protein TMS-1
    tumor differentially expressed 1
    tumor differentially expressed protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412441.1 → NP_001399370.1  serine incorporator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    2. NM_001412442.1 → NP_001399371.1  serine incorporator 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    3. NM_001412443.1 → NP_001399372.1  serine incorporator 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    4. NM_001412444.1 → NP_001399373.1  serine incorporator 3 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    5. NM_001412445.1 → NP_001399374.1  serine incorporator 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    6. NM_001412447.1 → NP_001399376.1  serine incorporator 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    7. NM_001412448.1 → NP_001399377.1  serine incorporator 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    8. NM_001412449.1 → NP_001399378.1  serine incorporator 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    9. NM_001412450.1 → NP_001399379.1  serine incorporator 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      UniProtKB/TrEMBL
      Q3TWZ3

    10. NM_001412451.1 → NP_001399380.1  serine incorporator 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    11. NM_001412452.1 → NP_001399381.1  serine incorporator 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    12. NM_001412453.1 → NP_001399382.1  serine incorporator 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    13. NM_001412454.1 → NP_001399383.1  serine incorporator 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    14. NM_001412455.1 → NP_001399384.1  serine incorporator 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    15. NM_001412456.1 → NP_001399385.1  serine incorporator 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    16. NM_012032.5 → NP_036162.3  serine incorporator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490
      Consensus CDS
      CCDS17013.1
      UniProtKB/Swiss-Prot
      Q3U7C6, Q62310, Q8BSP9, Q8CFD3, Q91VN9, Q9QZI9
      UniProtKB/TrEMBL
      Q3TWZ3
      Related
      ENSMUSP00000017851.4, ENSMUST00000017851.4
      Conserved Domains (1) summary
      pfam03348
      Location:16 → 470
      Serinc; Serine incorporator (Serinc)

    RNA

    1. NR_178197.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591488, AL591490

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163466577..163487767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499616.4 → XP_006499679.1  serine incorporator 3 isoform X2

      UniProtKB/TrEMBL
      Q3TWZ3
      Conserved Domains (1) summary
      pfam03348
      Location:1 → 415
      Serinc; Serine incorporator (Serinc)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZI9.2 GenPept UniProtKB/Swiss-Prot:Q9QZI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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