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    ChLD3 Chitin and LDLR binding deacetylase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ChLD3provided by FlyBase
    Official Full Name
    Chitin and LDLR binding deacetylase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032598
    Locus tag
    Dmel_CG17905
    See related
    AllianceGenome:FB:FBgn0032598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17905; DmCDA3; DmChLD3; Dmel\CG17905
    Summary
    Predicted to enable chitin deacetylase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ChLD3 in Genome Data Viewer
    Location:
    36A13-36A14; 2-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16738850..16742610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16738850..16742610)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Proteasome beta4 subunit Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Like Sm 7 Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein Neighboring gene yellow-b Neighboring gene pickpocket 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domain organization and phylogenetic analysis of proteins from the chitin deacetylase gene family of Tribolium castaneum and three other species of insects. Dixit R, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342249
    2. Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea. Wang S, et al. Curr Biol, 2006 Jan 24. PMID 16431370
    3. serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila. Luschnig S, et al. Curr Biol, 2006 Jan 24. PMID 16431371
    4. Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species. Tanaka KM, et al. BMC Ecol Evol, 2022 Jul 28. PMID 35902820, Free PMC Article
    5. Extracellular matrix and its receptors in Drosophila neural development. Broadie K, et al. Dev Neurobiol, 2011 Nov. PMID 21688401, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitin deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in extracellular region IKR
    Inferred from Key Residues
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chitin and LDLR binding deacetylase 3
    Names
    CG17905-PA
    ChLD3-PA
    NP_609806.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16738850..16742610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135962.3 → NP_609806.1  chitin and LDLR binding deacetylase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJI8
      Related
      FBpp0080449
      Conserved Domains (3) summary
      cd10974
      Location:243 → 512
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      cd00112
      Location:168 → 202
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01607
      Location:111 → 149
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJI8 Q9VJI8

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