Tpgs1 tubulin polyglutamylase complex subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpgs1provided by MGI
Official Full Name: tubulin polyglutamylase complex subunit 1provided by MGI
Primary source: MGI:MGI:106618
See related: Ensembl:ENSMUSG00000020308 AllianceGenome:MGI:106618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGs1; Gm16517; Gtrgeo22
Summary: Enables microtubule binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including adult behavior; protein polyglutamylation; and sperm axoneme assembly. Predicted to be located in centrosome and membrane. Predicted to be active in microtubule organizing center. Orthologous to human TPGS1 (tubulin polyglutamylase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 67.0), adrenal adult (RPKM 64.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79505273..79511961)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79669439..79676127)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutation results in a gross loss of alpha-tubulin polyglutamylation in brain, abnormal intracellular localization of a kinesin motor, KIF1A, and impaired synaptic transmission.
Title: Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.
constitutes a tubulin polyglutamylase complex.
Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
mutation results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat
Title: Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV211525 (e-PCR)
- UniSTS:160005

NoName (e-PCR)
- UniSTS:236395

AV005629 (e-PCR)
- UniSTS:164543

Madcam1 (e-PCR), detects polymorphism
- UniSTS:143809

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein polyglutamylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin polyglutamylase complex subunit 1

Names: PGs1 protein p32; gene trap ROSA b-geo 22; p32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_148934.3 → NP_683736.2 tubulin polyglutamylase complex subunit 1

Status: VALIDATED

Source sequence(s)

AC132265

Consensus CDS

CCDS23982.1

UniProtKB/Swiss-Prot

Q3U5Q9, Q99MS8, Q9R0B5

UniProtKB/TrEMBL

A0A6Q6PKE1, B2RRP1

Related

ENSMUSP00000020552.7, ENSMUST00000020552.8

Conserved Domains (1) summary

cl02594
Location:36 → 74

DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains