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    Tmem74 transmembrane protein 74 [ Mus musculus (house mouse) ]

    Gene ID: 239408, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem74provided by MGI
    Official Full Name
    transmembrane protein 74provided by MGI
    Primary source
    MGI:MGI:2443417
    See related
    Ensembl:ENSMUSG00000054409 AllianceGenome:MGI:2443417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230382K22Rik
    Summary
    Enables transmembrane transporter binding activity. Acts upstream of or within general adaptation syndrome, behavioral process and regulation of cation channel activity. Located in plasma membrane. Is expressed in cerebral cortex subventricular zone and cortical plate. Orthologous to human TMEM74 (transmembrane protein 74). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.9), whole brain E14.5 (RPKM 1.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem74 in Genome Data Viewer
    Location:
    15 B3.2; 15 16.82 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (43726741..43733462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43863345..43870059, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38554 Neighboring gene predicted gene, 53880 Neighboring gene predicted gene, 41316 Neighboring gene ER membrane protein complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_38556 Neighboring gene STARR-seq mESC enhancer starr_38557 Neighboring gene STARR-seq mESC enhancer starr_38558 Neighboring gene STARR-seq mESC enhancer starr_38559 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38560 Neighboring gene STARR-seq mESC enhancer starr_38561 Neighboring gene STARR-seq mESC enhancer starr_38563 Neighboring gene STARR-seq mESC enhancer starr_38565 Neighboring gene STARR-seq mESC enhancer starr_38567 Neighboring gene thyrotropin releasing hormone receptor Neighboring gene predicted gene, 33793

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. Shao LX, et al. Mol Psychiatry, 2019 Oct. PMID 30886335
    2. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Yu C, et al. Science, 2013 Dec 20. PMID 24357321
    3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within general adaptation syndrome, behavioral process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within general adaptation syndrome, behavioral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 74

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175502.3 → NP_780711.1  transmembrane protein 74

      See identical proteins and their annotated locations for NP_780711.1

      Status: PROVISIONAL

      Source sequence(s)
      AK046420
      Consensus CDS
      CCDS27454.1
      UniProtKB/Swiss-Prot
      Q8BQU7
      Related
      ENSMUSP00000070748.5, ENSMUST00000067469.6
      Conserved Domains (1) summary
      pfam14927
      Location:177 → 262
      Neurensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      43726741..43733462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520908.5 → XP_006520971.2  transmembrane protein 74 isoform X1

      UniProtKB/Swiss-Prot
      Q8BQU7
      Conserved Domains (1) summary
      pfam14927
      Location:177 → 262
      Neurensin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQU7.1 GenPept UniProtKB/Swiss-Prot:Q8BQU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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