Ptma prothymosin alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptmaprovided by MGI
Official Full Name: prothymosin alphaprovided by MGI
Primary source: MGI:MGI:97803
See related: Ensembl:ENSMUSG00000026238 AllianceGenome:MGI:97803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thym
Summary: Enables histone binding activity and histone chaperone activity. Involved in chromatin organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; extraembryonic component; and genitourinary system. Used to study polycystic kidney disease and pulmonary emphysema. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 1626.5), CNS E14 (RPKM 884.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.96 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (86454442..86458434)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86526557..86530712)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prothymosin alpha Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2.
Title: Prothymosin α Plays Role as a Brain Guardian through Ecto-F(1) ATPase-P2Y(12) Complex and TLR4/MD2.
Thymosin alpha1 protects from CTLA-4 intestinal immunopathology.
Title: Thymosin α1 protects from CTLA-4 intestinal immunopathology.
Prothymosin alpha activates type I collagen to develop a fibrotic placenta in gestational diabetes.
Title: Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes.
Ggamma7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety.
Title: Gγ7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety.
results elucidate the significant role of Prothymosin alpha, including protein acetylation and STAT3 activation in polycystic kidney disease (PKD), which represent potential for ameliorating the disease progression of PKD
Title: Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice.
Prothymosin alpha-knockout mice showed an impaired long-term potentiation induction in the hippocampus along with decreased neurogenesis.
Title: Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis.
Prothymosin-alpha variants elicit anti-HIV-1 response via TLR4 dependent and independent pathways.
Title: Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.
These results demonstrate the clinical relevance of prothymosin alpha in regulating acetylation events during the pathogenesis of emphysema.
Title: Prothymosin α overexpression contributes to the development of pulmonary emphysema.
Only neurons possess the specific mechanisms required to release prothymosin-alpha following cerebral ischemic stress in vivo.
Title: Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.
Regional distribution and cell type-specific subcellular localization of Prothymosin alpha in brain.
Title: Regional distribution and cell type-specific subcellular localization of Prothymosin alpha in brain.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prothymosin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360830.2 → NP_001347759.1 prothymosin alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC158132

Conserved Domains (1) summary

pfam03247
Location:2 → 53

Prothymosin; Prothymosin/parathymosin family
NM_001360831.2 → NP_001347760.1 prothymosin alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158132

Conserved Domains (1) summary

pfam03247
Location:2 → 47

Prothymosin; Prothymosin/parathymosin family
NM_008972.4 → NP_032998.1 prothymosin alpha isoform 1

See identical proteins and their annotated locations for NP_032998.1

Status: VALIDATED

Source sequence(s)

AC158132

Consensus CDS

CCDS35649.1

UniProtKB/Swiss-Prot

P26350, Q3UQV6

UniProtKB/TrEMBL

Q0VGU2, Q3U6E4

Related

ENSMUSP00000044188.9, ENSMUST00000045897.15

Conserved Domains (1) summary

pfam03247
Location:2 → 110

Prothymosin; Prothymosin/parathymosin family