Odf1 outer dense fiber of sperm tails 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odf1provided by MGI
Official Full Name: outer dense fiber of sperm tails 1provided by MGI
Primary source: MGI:MGI:97424
See related: Ensembl:ENSMUSG00000061923 AllianceGenome:MGI:97424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein domain specific binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in manchette and outer dense fiber. Is expressed in parathyroid gland; testis; and thyroid gland. Orthologous to human ODF1 (outer dense fiber of sperm tails 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 1293.5) See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (38219447..38226979)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (38219203..38226735)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
Title: Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.
Severe male subfertility provoked by haplo-deficiency of ODF1 is therefore most probably caused by impaired head-to-tail coupling that eventually might induce sperm decapitation on the specific conditions of in vivo fertilisation.
Title: Haplo-deficiency of ODF1/HSPB10 in mouse sperm causes relaxation of head-to-tail linkage.
Heterozygous mutant male mice are fertile while sperm motility is reduced, but Odf1-deficient male mice are infertile due to the detachment of the sperm head.
Title: The small heat shock protein ODF1/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice.
Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.
Title: Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495476

Odf1 (e-PCR), detects polymorphism
- UniSTS:526974

NoName (e-PCR)
- UniSTS:489092

NoName (e-PCR)
- UniSTS:482011

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in manchette	IDA Inferred from Direct Assay more info	PubMed
is_active_in outer dense fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in outer dense fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in outer dense fiber	IPI Inferred from Physical Interaction more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: outer dense fiber protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008757.3 → NP_032783.2 outer dense fiber protein 1

See identical proteins and their annotated locations for NP_032783.2

Status: VALIDATED

Source sequence(s)

BC145758, BX632868, CJ042343

Consensus CDS

CCDS49596.1

UniProtKB/Swiss-Prot

Q61999

UniProtKB/TrEMBL

A6H656

Related

ENSMUSP00000080632.5, ENSMUST00000081966.5

Conserved Domains (1) summary

cd06482
Location:102 → 188

ACD_HspB10; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell ...