Tpm2 tropomyosin 2, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpm2provided by MGI
Official Full Name: tropomyosin 2, betaprovided by MGI
Primary source: MGI:MGI:98810
See related: Ensembl:ENSMUSG00000028464 AllianceGenome:MGI:98810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tpm-2; Trop-2
Summary: This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Expression: Biased expression in bladder adult (RPKM 555.0), mammary gland adult (RPKM 100.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43513726..43523583, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43513726..43523583, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC).
Title: Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC).
Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and is a novel prognostic biomarker.
Title: Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and is a novel prognostic biomarker.
Trop2 Deficiency Reduces the Protective Effect of cortical bone-derived stem cells on Myocardial Ischemia/Reperfusion Injury.
Title: Trop2 Guarantees Cardioprotective Effects of Cortical Bone-Derived Stem Cells on Myocardial Ischemia/Reperfusion Injury.
Tpm2 is involved in the progression of EMT during the wound healing process of mouse epithelial cells, suggesting that inhibition of Tpm2 may suppress Posterior capsular opacification.
Title: Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity.
Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.
Title: FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program.
Title: Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.
Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa.
Title: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.
our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells
Title: Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs.
data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK pathway and several critical components of the cell migration apparatus
Title: Trop2 regulates motility and lamellipodia formation in cultured fetal lung fibroblasts.
Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
Title: Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle thin filament tropomyosin	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tropomyosin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277875.1 → NP_001264804.1 tropomyosin beta chain isoform Tpm2.3

See identical proteins and their annotated locations for NP_001264804.1

Status: REVIEWED

Description

Transcript Variant: This variant (Tpm2.3, also known as variant 2) uses an alternate splice site in the 3' coding region, compared to variant Tpm2.2. It encodes isoform Tpm2.3 (also known as isoform 2) which is of the same size, but has a distinct C-terminus, compared to isoform Tpm2.2st.

Source sequence(s)

AK132162, BY439632, BY786644, DV049735

UniProtKB/TrEMBL

Q61344

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001277876.1 → NP_001264805.1 tropomyosin beta chain isoform Tpm2.1sm/cy

See identical proteins and their annotated locations for NP_001264805.1

Status: REVIEWED

Description

Transcript Variant: This variant (Tpm2.1, also known as variant 3) differs in the 3' UTR and has multiple differences in the 3' coding region, compared to variant Tpm2.2. It encodes isoform Tpm2.1sm/cy (also known as isoform 3), which is of the same size but has a different internal segment and a distinct C-terminus, compared to isoform Tpm2.2st.

Source sequence(s)

AA208641, AK132162, BY786644, CV560790

Consensus CDS

CCDS71374.1

UniProtKB/TrEMBL

Q6PJ18

Related

ENSMUSP00000103547.4, ENSMUST00000107914.10

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_009416.4 → NP_033442.2 tropomyosin beta chain isoform Tpm2.2st

See identical proteins and their annotated locations for NP_033442.2

Status: REVIEWED

Description

Transcript Variant: This variant (Tpm2.2, also known as variant 1) represents the longest transcript and encodes isoform Tpm2.2st (also known as isoform 1), which is of the same size as isoforms Tpm2.1sm/cy and Tpm2.3.

Source sequence(s)

AK003186, AK132162, BY786644

Consensus CDS

CCDS18100.1

UniProtKB/Swiss-Prot

P46901, P58774

UniProtKB/TrEMBL

Q9D1R6

Related

ENSMUSP00000103546.4, ENSMUST00000107913.10

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin