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    SYT17 synaptotagmin 17 [ Homo sapiens (human) ]

    Gene ID: 51760, updated on 3-Dec-2024

    Summary

    Official Symbol
    SYT17provided by HGNC
    Official Full Name
    synaptotagmin 17provided by HGNC
    Primary source
    HGNC:HGNC:24119
    See related
    Ensembl:ENSG00000103528 AllianceGenome:HGNC:24119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Syt-17; sytXVII
    Summary
    Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Involved in positive regulation of dendrite extension and regulation of postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 8.9), prostate (RPKM 3.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SYT17 in Genome Data Viewer
    Location:
    16p12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (19167834..19268332)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19098689..19198945)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19179156..19279654)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7242 Neighboring gene ITPRIP like 2 Neighboring gene uncharacterized LOC124903657 Neighboring gene Sharpr-MPRA regulatory region 12181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19179399-19180146 Neighboring gene uncharacterized LOC124903658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19195968-19196784 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:19204058-19204226 Neighboring gene C-type lectin domain containing 19A Neighboring gene uncharacterized LOC124903781

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-17
    Names
    B/K protein
    synaptotagmin XVII

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308157.2NP_001295086.1  synaptotagmin-17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA705977, AC003003, AC010494, AK098747
      Consensus CDS
      CCDS76835.1
      UniProtKB/TrEMBL
      B4DJB2, H3BN78
      Related
      ENSP00000454721.2, ENST00000562711.6
      Conserved Domains (2) summary
      cd08390
      Location:182310
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:319453
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    2. NM_001330509.2NP_001317438.1  synaptotagmin-17 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' terminal exon which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA705977, AC003003, AC010494
      Consensus CDS
      CCDS81952.1
      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    3. NM_001410903.1NP_001397832.1  synaptotagmin-17 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC003003, AC010494
      Consensus CDS
      CCDS92119.1
      UniProtKB/TrEMBL
      B4DJB2, H3BQZ6
      Related
      ENSP00000456009.1, ENST00000568115.5
    4. NM_016524.4NP_057608.2  synaptotagmin-17 isoform 1

      See identical proteins and their annotated locations for NP_057608.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA705977, AC003003, AC010494, BC004518
      Consensus CDS
      CCDS10575.1
      UniProtKB/Swiss-Prot
      O43330, Q9BSW7, Q9NZ18
      UniProtKB/TrEMBL
      B4DJB2
      Related
      ENSP00000347538.2, ENST00000355377.7
      Conserved Domains (2) summary
      cd08390
      Location:186314
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:323457
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      19167834..19268332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434203.1XP_047290159.1  synaptotagmin-17 isoform X1

      UniProtKB/TrEMBL
      B4DJB2
    2. XM_047434206.1XP_047290162.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    3. XM_024450297.2XP_024306065.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    4. XM_047434204.1XP_047290160.1  synaptotagmin-17 isoform X3

    5. XM_011545869.3XP_011544171.1  synaptotagmin-17 isoform X7

      See identical proteins and their annotated locations for XP_011544171.1

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    6. XM_011545871.3XP_011544173.1  synaptotagmin-17 isoform X7

      See identical proteins and their annotated locations for XP_011544173.1

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    7. XM_011545868.2XP_011544170.1  synaptotagmin-17 isoform X4

      UniProtKB/TrEMBL
      B4DJB2
      Conserved Domains (2) summary
      cd08390
      Location:180308
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:317451
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    8. XM_011545872.3XP_011544174.1  synaptotagmin-17 isoform X7

      See identical proteins and their annotated locations for XP_011544174.1

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    9. XM_017023280.2XP_016878769.1  synaptotagmin-17 isoform X5

    10. XM_047434205.1XP_047290161.1  synaptotagmin-17 isoform X6

    11. XM_011545866.4XP_011544168.1  synaptotagmin-17 isoform X2

      UniProtKB/TrEMBL
      B4DJB2
      Conserved Domains (2) summary
      cd08390
      Location:193321
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:330464
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    12. XM_017023281.2XP_016878770.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
      Related
      ENSP00000456252.1, ENST00000562034.5
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      19098689..19198945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380451.1XP_054236426.1  synaptotagmin-17 isoform X1

      UniProtKB/TrEMBL
      B4DJB2
    2. XM_054380461.1XP_054236436.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    3. XM_054380462.1XP_054236437.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    4. XM_054380453.1XP_054236428.1  synaptotagmin-17 isoform X3

    5. XM_054380458.1XP_054236433.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    6. XM_054380459.1XP_054236434.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    7. XM_054380454.1XP_054236429.1  synaptotagmin-17 isoform X4

      UniProtKB/TrEMBL
      B4DJB2
    8. XM_054380457.1XP_054236432.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9
    9. XM_054380455.1XP_054236430.1  synaptotagmin-17 isoform X5

    10. XM_054380456.1XP_054236431.1  synaptotagmin-17 isoform X6

    11. XM_054380452.1XP_054236427.1  synaptotagmin-17 isoform X2

      UniProtKB/TrEMBL
      B4DJB2
    12. XM_054380460.1XP_054236435.1  synaptotagmin-17 isoform X7

      UniProtKB/TrEMBL
      B4DJB2, H3BRH9