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    MARK1 microtubule affinity regulating kinase 1 [ Homo sapiens (human) ]

    Gene ID: 4139, updated on 3-Dec-2024

    Summary

    Official Symbol
    MARK1provided by HGNC
    Official Full Name
    microtubule affinity regulating kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:6896
    See related
    Ensembl:ENSG00000116141 MIM:606511; AllianceGenome:HGNC:6896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MARK; Par1c; Par-1c
    Summary
    Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MARK1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (220528136..220664461)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (219767527..219904166)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220701478..220837803)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372928 Neighboring gene long intergenic non-protein coding RNA 2779 Neighboring gene Sharpr-MPRA regulatory region 1437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1825 Neighboring gene RNA, 7SL, cytoplasmic 464, pseudogene Neighboring gene histone deacetylase 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:220856220-220856720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1826 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:220869747-220870946 Neighboring gene chromosome 1 open reading frame 115 Neighboring gene uncharacterized LOC124904516 Neighboring gene mitochondrial amidoxime reducing component 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    EBI GWAS Catalog
    Genome-wide association study in bipolar patients stratified by co-morbidity.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of MAP/microtubule affinity-regulating kinase 1 (MARK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1477, MGC126512, MGC126513

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tau-protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tau-protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of mitochondrion localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK1
    Names
    MAP/microtubule affinity-regulating kinase 1
    PAR1 homolog c
    NP_001273053.1
    NP_001273055.1
    NP_001273057.1
    NP_001273058.1
    NP_061120.3
    XP_005273191.1
    XP_006711389.1
    XP_011507863.1
    XP_011507864.1
    XP_016856794.1
    XP_024302858.1
    XP_047276800.1
    XP_054192613.1
    XP_054192614.1
    XP_054192615.1
    XP_054192616.1
    XP_054192617.1
    XP_054192618.1
    XP_054192619.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286124.2NP_001273053.1  serine/threonine-protein kinase MARK1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC096640, AK314614, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS73033.1
      UniProtKB/TrEMBL
      A0A087X0I6, X5DNR8
      Related
      ENSP00000483424.1, ENST00000611084.4
      Conserved Domains (4) summary
      cd12196
      Location:697794
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001286126.2NP_001273055.1  serine/threonine-protein kinase MARK1 isoform 3

      See identical proteins and their annotated locations for NP_001273055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC096640, AK295506, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS73034.1
      UniProtKB/TrEMBL
      B4DIB3, X5DNR8
      Related
      ENSP00000386017.2, ENST00000402574.5
      Conserved Domains (4) summary
      cd12196
      Location:681778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001286128.2NP_001273057.1  serine/threonine-protein kinase MARK1 isoform 4

      See identical proteins and their annotated locations for NP_001273057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AB040910, AC096640, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS65789.1
      UniProtKB/TrEMBL
      A0A7I2V550
      Related
      ENSP00000355885.4, ENST00000366918.8
      Conserved Domains (4) summary
      cd12196
      Location:659756
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:309349
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:59289
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001286129.2NP_001273058.1  serine/threonine-protein kinase MARK1 isoform 5

      See identical proteins and their annotated locations for NP_001273058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC096640, BC068608
      UniProtKB/TrEMBL
      A0A7I2V4P8
      Conserved Domains (1) summary
      cl21453
      Location:59105
      PKc_like; Protein Kinases, catalytic domain
    5. NM_018650.5NP_061120.3  serine/threonine-protein kinase MARK1 isoform 2

      See identical proteins and their annotated locations for NP_061120.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC096640, AL592406, BC068608, BC113869, CA412112
      Consensus CDS
      CCDS31029.2
      UniProtKB/Swiss-Prot
      D3DTB0, D3DTB1, Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P0L2, Q9P251
      UniProtKB/TrEMBL
      X5DNR8
      Related
      ENSP00000355884.5, ENST00000366917.6
      Conserved Domains (4) summary
      cd12196
      Location:696793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      220528136..220664461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001305.3XP_016856794.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Related
      ENSP00000503257.1, ENST00000678435.1
      Conserved Domains (4) summary
      cd12196
      Location:587684
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:1201
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:221261
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:1201
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005273134.6XP_005273191.1  serine/threonine-protein kinase MARK1 isoform X3

      See identical proteins and their annotated locations for XP_005273191.1

      UniProtKB/TrEMBL
      X5D2M4, X5DNR8
      Conserved Domains (4) summary
      cd12196
      Location:682779
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_024447090.2XP_024302858.1  serine/threonine-protein kinase MARK1 isoform X6

      Conserved Domains (1) summary
      cd14072
      Location:59303
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_011509561.4XP_011507863.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      X5DNR8
      Conserved Domains (4) summary
      cd12196
      Location:689786
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:52303
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:323363
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:51303
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_047420844.1XP_047276800.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      X5DNR8
    6. XM_006711326.5XP_006711389.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Conserved Domains (4) summary
      cd12196
      Location:609706
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:15223
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:243283
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:10223
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011509562.4XP_011507864.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Conserved Domains (4) summary
      cd12196
      Location:587684
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:1201
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:221261
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:1201
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      219767527..219904166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336642.1XP_054192617.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
    2. XM_054336640.1XP_054192615.1  serine/threonine-protein kinase MARK1 isoform X3

      UniProtKB/TrEMBL
      X5D2M4, X5DNR8
    3. XM_054336644.1XP_054192619.1  serine/threonine-protein kinase MARK1 isoform X6

    4. XM_054336638.1XP_054192613.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      X5DNR8
    5. XM_054336639.1XP_054192614.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      X5DNR8
    6. XM_054336641.1XP_054192616.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2YQC1
    7. XM_054336643.1XP_054192618.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1