NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001286124.2 → NP_001273053.1 serine/threonine-protein kinase MARK1 isoform 1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AC096640, AK314614, AL592406, BC068608, CA412112
- Consensus CDS
-
CCDS73033.1
- UniProtKB/TrEMBL
- A0A087X0I6, X5DNR8
- Related
- ENSP00000483424.1, ENST00000611084.4
- Conserved Domains (4) summary
-
- cd12196
Location:697 → 794
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:60 → 311
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:331 → 371
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cd14072
Location:59 → 311
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
-
NM_001286126.2 → NP_001273055.1 serine/threonine-protein kinase MARK1 isoform 3
See identical proteins and their annotated locations for NP_001273055.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
- Source sequence(s)
-
AC096640, AK295506, AL592406, BC068608, CA412112
- Consensus CDS
-
CCDS73034.1
- UniProtKB/TrEMBL
- B4DIB3, X5DNR8
- Related
- ENSP00000386017.2, ENST00000402574.5
- Conserved Domains (4) summary
-
- cd12196
Location:681 → 778
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:60 → 311
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:331 → 371
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cd14072
Location:59 → 311
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
-
NM_001286128.2 → NP_001273057.1 serine/threonine-protein kinase MARK1 isoform 4
See identical proteins and their annotated locations for NP_001273057.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
- Source sequence(s)
-
AB040910, AC096640, AL592406, BC068608, CA412112
- Consensus CDS
-
CCDS65789.1
- UniProtKB/TrEMBL
-
A0A7I2V550
- Related
- ENSP00000355885.4, ENST00000366918.8
- Conserved Domains (4) summary
-
- cd12196
Location:659 → 756
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:60 → 289
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:309 → 349
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cl21453
Location:59 → 289
- PKc_like; Protein Kinases, catalytic domain
-
NM_001286129.2 → NP_001273058.1 serine/threonine-protein kinase MARK1 isoform 5
See identical proteins and their annotated locations for NP_001273058.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
- Source sequence(s)
-
AC096640, BC068608
- UniProtKB/TrEMBL
-
A0A7I2V4P8
- Conserved Domains (1) summary
-
- cl21453
Location:59 → 105
- PKc_like; Protein Kinases, catalytic domain
-
NM_018650.5 → NP_061120.3 serine/threonine-protein kinase MARK1 isoform 2
See identical proteins and their annotated locations for NP_061120.3
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
- Source sequence(s)
-
AC096640, AL592406, BC068608, BC113869, CA412112
- Consensus CDS
-
CCDS31029.2
- UniProtKB/Swiss-Prot
- D3DTB0, D3DTB1, Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P0L2, Q9P251
- UniProtKB/TrEMBL
-
X5DNR8
- Related
- ENSP00000355884.5, ENST00000366917.6
- Conserved Domains (4) summary
-
- cd12196
Location:696 → 793
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:60 → 311
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:331 → 371
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cd14072
Location:59 → 311
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
220528136..220664461
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017001305.3 → XP_016856794.1 serine/threonine-protein kinase MARK1 isoform X5
- UniProtKB/TrEMBL
-
A0A7I2YQC1
- Related
- ENSP00000503257.1, ENST00000678435.1
- Conserved Domains (4) summary
-
- cd12196
Location:587 → 684
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:1 → 201
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:221 → 261
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cl21453
Location:1 → 201
- PKc_like; Protein Kinases, catalytic domain
-
XM_005273134.6 → XP_005273191.1 serine/threonine-protein kinase MARK1 isoform X3
See identical proteins and their annotated locations for XP_005273191.1
- UniProtKB/TrEMBL
- X5D2M4, X5DNR8
- Conserved Domains (4) summary
-
- cd12196
Location:682 → 779
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:60 → 311
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:331 → 371
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cd14072
Location:59 → 311
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
-
XM_024447090.2 → XP_024302858.1 serine/threonine-protein kinase MARK1 isoform X6
- Conserved Domains (1) summary
-
- cd14072
Location:59 → 303
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
-
XM_011509561.4 → XP_011507863.1 serine/threonine-protein kinase MARK1 isoform X1
- UniProtKB/TrEMBL
-
X5DNR8
- Conserved Domains (4) summary
-
- cd12196
Location:689 → 786
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:52 → 303
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:323 → 363
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cd14072
Location:51 → 303
- STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
-
XM_047420844.1 → XP_047276800.1 serine/threonine-protein kinase MARK1 isoform X2
- UniProtKB/TrEMBL
-
X5DNR8
-
XM_006711326.5 → XP_006711389.1 serine/threonine-protein kinase MARK1 isoform X4
- UniProtKB/TrEMBL
-
A0A7I2YQC1
- Conserved Domains (4) summary
-
- cd12196
Location:609 → 706
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:15 → 223
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:243 → 283
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cl21453
Location:10 → 223
- PKc_like; Protein Kinases, catalytic domain
-
XM_011509562.4 → XP_011507864.1 serine/threonine-protein kinase MARK1 isoform X5
- UniProtKB/TrEMBL
-
A0A7I2YQC1
- Conserved Domains (4) summary
-
- cd12196
Location:587 → 684
- MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
- smart00220
Location:1 → 201
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14405
Location:221 → 261
- UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
- cl21453
Location:1 → 201
- PKc_like; Protein Kinases, catalytic domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
219767527..219904166
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054336642.1 → XP_054192617.1 serine/threonine-protein kinase MARK1 isoform X5
- UniProtKB/TrEMBL
-
A0A7I2YQC1
-
XM_054336640.1 → XP_054192615.1 serine/threonine-protein kinase MARK1 isoform X3
- UniProtKB/TrEMBL
- X5D2M4, X5DNR8
-
XM_054336644.1 → XP_054192619.1 serine/threonine-protein kinase MARK1 isoform X6
-
XM_054336638.1 → XP_054192613.1 serine/threonine-protein kinase MARK1 isoform X1
- UniProtKB/TrEMBL
-
X5DNR8
-
XM_054336639.1 → XP_054192614.1 serine/threonine-protein kinase MARK1 isoform X2
- UniProtKB/TrEMBL
-
X5DNR8
-
XM_054336641.1 → XP_054192616.1 serine/threonine-protein kinase MARK1 isoform X4
- UniProtKB/TrEMBL
-
A0A7I2YQC1
-
XM_054336643.1 → XP_054192618.1 serine/threonine-protein kinase MARK1 isoform X5
- UniProtKB/TrEMBL
-
A0A7I2YQC1