Rab38 RAB38, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab38provided by RGD
Official Full Name: RAB38, member RAS oncogene familyprovided by RGD
Primary source: RGD:628752
See related: EnsemblRapid:ENSRNOG00000016769 AllianceGenome:RGD:628752
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ruby
Summary: Enables GTP binding activity. Involved in platelet dense granule organization; positive regulation of biosynthetic process; and positive regulation of protein localization to cell periphery. Located in cell body; melanosome; and perinuclear region of cytoplasm. Used to study Hermansky-Pudlak syndrome and proteinuria. Orthologous to human RAB38 (RAB38, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 169.1), Lung (RPKM 154.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (151595153..151675492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (142182566..142262923)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (152072716..152153449)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In an experimental diabetes model, Rab38 knockout rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface compared to control rats.
Title: Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Rab38 affects urinary protein excretion via effects in the proximal tubule.
Title: Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.
Title: Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.
Data show that Rab38-deficient type II cells appear to carry abnormality in lung surfactant secretion but not in synthesis or uptake.
Title: Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome.
Rab38 may play a role in the development of dense granules in the megakaryocytes and platelets
Title: The role of Rab38 in platelet dense granule defects.
First report of gene responsible for quantitative trait locus linked to proteinuria in model of hypertension-associated ESRD. Rab38 influiences proteinuria independently of glomerular damage.
Title: RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat.
results indicate that Rab38 is expressed non-ubiquitously in specific tissues & regulates early vesicle transport relating to the endoplasmic reticulum; suggested that Rab38 abnormality may cause multiple organ diseases as well as oculocutaneous albinism
Title: Expression and characterization of Rab38, a new member of the Rab small G protein family.

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General gene information

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Markers

RH135407 (e-PCR)
- UniSTS:218684

RH143545 (e-PCR)
- UniSTS:232791

AU043391 (e-PCR)
- UniSTS:159667

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AP-1 adaptor complex binding	ISO Inferred from Sequence Orthology more info
NOT enables AP-2 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables AP-3 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables BLOC-2 complex binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	IC Inferred by Curator more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IC Inferred by Curator more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome assembly	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in phagosome acidification	ISO Inferred from Sequence Orthology more info
involved_in platelet dense granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to cell periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
NOT located_in early endosome lumen	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-38

Names: Rab38, member of RAS oncogene family; red eyed dilution; ruby or red eyed dilution; small GTP binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.