KT1 K+ transporter 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KT1
Official Full Name: K+ transporter 1
Primary source: TAIR:AT2G26650
Locus tag: AT2G26650
See related: Araport:AT2G26650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AKT1; ATAKT1; F18A8.2; F18A8_2; K+ transporter 1; POTASSIUM TRANSPORTER
Summary: Encodes AKT1, a member of the Shaker family inward rectifying potassium channel predominantly expressed in predominantly in root hairs and root endodermis. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581: 2357): I (inward rectifying channel): AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel): KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel): AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation): KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel): SKOR (AT3G02850) and GORK (AT5G37500).
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Genomic context

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See KT1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (11331850..11336738, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WRKY6 transcription factor modulates root potassium acquisition through promoting expression of AKT1 in Arabidopsis.
Title: WRKY6 transcription factor modulates root potassium acquisition through promoting expression of AKT1 in Arabidopsis.
AKT1 and AtHak5 are associated with both uptake and translocation of Potassium in Arabidopsis.
Title: Modulation of K(+) translocation by AKT1 and AtHAK5 in Arabidopsis plants.
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
Title: AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP, which further represses the activity of K(+) channel AKT1 in Arabidopsis.
Title: Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
Title: Capacity and plasticity of potassium channels and high-affinity transporters in roots of barley and Arabidopsis.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
Title: Disruption of the Arabidopsis thaliana inward-rectifier K+ channel AKT1 improves plant responses to water stress.
These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.
Title: Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA interactions.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
Title: Potassium channel alpha-subunit AtKC1 negatively regulates AKT1-mediated K(+) uptake in Arabidopsis roots under low-K(+) stress.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
Title: High-affinity K(+) transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
Title: Studies on Arabidopsis athak5, atakt1 double mutants disclose the range of concentrations at which AtHAK5, AtAKT1 and unknown systems mediate K uptake.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001336078.1

Supported by ESTs:

NM_128222.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion transport	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: K+ transporter 1

NP_180233.1

K+ transporter 1 (KT1); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Protein of unknown function DUF3354 (InterPro:IPR021789), Ion transport (InterPro:IPR005821), Ankyrin repeat-containing domain (InterPro:IPR020683), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: K+ transporter 5 (TAIR:AT4G32500.1); Has 86170 Blast hits to 36402 proteins in 1811 species: Archae - 161; Bacteria - 9078; Metazoa - 42367; Fungi - 8163; Plants - 4219; Viruses - 1188; Other Eukaryotes - 20994 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11331850..11336738 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128222.6 → NP_180233.1 K+ transporter 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180233.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DI19, Q0WTF6, Q38797, Q38998, Q84MA7

UniProtKB/TrEMBL

A0A178VS17, A0A654EWF2

Conserved Domains (2) summary

PLN03192
Location:26 → 856

PLN03192; Voltage-dependent potassium channel; Provisional

sd00045
Location:550 → 581

ANK; ANK repeat [structural motif]
NM_001336078.1 → NP_001324538.1 K+ transporter 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B0E9, A0A654EWF2