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    ROL5 repressor of lrx1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819035, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROL5
    Official Full Name
    repressor of lrx1
    Primary source
    TAIR:AT2G44270
    Locus tag
    AT2G44270
    See related
    Araport:AT2G44270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4I1.8; repressor of lrx1
    Summary
    Encodes ROL5, a repressor of lrx1 mutants that develop aberrant root hairs. ROL5 is a homolog of yeast Ncs6p that affects TOR signaling. The target of rapamycin (TOR) pathway is a major regulator of cell growth in eukaryotes, and inhibition of this pathway by rapamycin reduces cell growth. ROL5 might function as a mitochondrial component of the TOR pathway that influences the plant's response to ROS (reactive oxygen species).
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    Genomic context

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    See ROL5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (18297878..18300304, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-splicing ligase, putative (DUF239) Neighboring gene ncRNA Neighboring gene DUF946 family protein (DUF946) Neighboring gene ncRNA Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytosolic thiouridylase CTU2 of Arabidopsis thaliana is essential for posttranscriptional thiolation of tRNAs and influences root development. Philipp M, et al. BMC Plant Biol, 2014 Apr 28. PMID 24774365, Free PMC Article
    2. The TOR pathway modulates the structure of cell walls in Arabidopsis. Leiber RM, et al. Plant Cell, 2010 Jun. PMID 20530756, Free PMC Article
    3. Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway. Iñigo S, et al. Plant Physiol, 2016 Oct. PMID 27503603, Free PMC Article
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of plant-type cell wall organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    repressor of lrx1
    NP_181956.2
    • repressor of lrx1 (ROL5); FUNCTIONS IN: ATP binding; INVOLVED IN: response to reactive oxygen species, regulation of plant-type cell wall organization or biogenesis; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Uncharacterised protein family UPF0021, C-terminal (InterPro:IPR000541), PP-loop (InterPro:IPR011063), 2-thiocytidine tRNA biosynthesis protein, TtcA (InterPro:IPR012089); BEST Arabidopsis thaliana protein match is: 2-thiocytidine tRNA biosynthesis protein, TtcA (TAIR:AT1G76170.1); Has 5057 Blast hits to 4981 proteins in 1812 species: Archae - 336; Bacteria - 3752; Metazoa - 169; Fungi - 215; Plants - 64; Viruses - 0; Other Eukaryotes - 521 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18297878..18300304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129991.3 → NP_181956.2  repressor of lrx1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181956.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64862, Q8GZ19
      UniProtKB/TrEMBL
      A0A178VUZ0, A0A5S9X772, A0A654FCD4
      Conserved Domains (2) summary
      cd01993
      Location:61 → 247
      Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
      cl25646
      Location:211 → 312
      zn-ribbon_14; Zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64862.2

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