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    CXXS2 C-terminal cysteine residue is changed to a serine 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818676, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CXXS2
    Official Full Name
    C-terminal cysteine residue is changed to a serine 2
    Primary source
    TAIR:AT2G40790
    Locus tag
    AT2G40790
    See related
    Araport:AT2G40790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCXXS2; C-terminal cysteine residue is changed to a serine 2; T7D17.3; T7D17_3
    Summary
    Encodes a monocysteinic thioredoxin, thioredoxin in which the second cysteine of the redox site is replaced by a serine, with low disulfide reductase but efficient disulfide isomerase activity. It contains a large N-terminal extension with respect to the dicysteinic thioredoxins that is enriched with 8 cysteines and positively charged residues.
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    Genomic context

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    See CXXS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (17022952..17024301, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing protein Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene import inner membrane translocase subunit Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity. Serrato AJ, et al. Physiol Plant, 2008 Jul. PMID 18384502
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001336864.1
    NM_129642.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein deglutathionylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-terminal cysteine residue is changed to a serine 2
    NP_001318396.1
    • C-terminal cysteine residue is changed to a serine 2 (CXXS2); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: N-terminal protein myristoylation, protein thiol-disulfide exchange; LOCATED IN: cytosol; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT3G56420.1); Has 10001 Blast hits to 9985 proteins in 2467 species: Archae - 182; Bacteria - 5375; Metazoa - 1057; Fungi - 645; Plants - 1031; Viruses - 5; Other Eukaryotes - 1706 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17022952..17024301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336864.1 → NP_001318396.1  C-terminal cysteine residue is changed to a serine 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38878, Q8GXV2
      UniProtKB/TrEMBL
      A0A5S9X5U7, A0A654F0P6, A0A7G2EJ73
      Conserved Domains (1) summary
      cd02947
      Location:49 → 138
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    2. NM_129642.4 → NP_181611.2  C-terminal cysteine residue is changed to a serine 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181611.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38878, Q8GXV2
      UniProtKB/TrEMBL
      A0A5S9X5U7, A0A654F0P6, A0A7G2EJ73
      Conserved Domains (1) summary
      cd02947
      Location:49 → 138
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXV2.1

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