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    NDB4 NAD(P)H dehydrogenase B4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816609, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NDB4
    Official Full Name
    NAD(P)H dehydrogenase B4
    Primary source
    TAIR:AT2G20800
    Locus tag
    AT2G20800
    See related
    Araport:AT2G20800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5H14.23; F5H14_23; NAD(P)H dehydrogenase B4
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    Genomic context

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    See NDB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (8953057..8955831, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GCR2-like 2 Neighboring gene Major facilitator superfamily protein Neighboring gene clathrin adaptor complexes medium subunit family protein Neighboring gene uncharacterized protein Neighboring gene DNA-binding storekeeper protein transcriptional regulator-like protein Neighboring gene galacturonosyltransferase 10 Neighboring gene QWRF motif protein (DUF566)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alterations in the mitochondrial alternative NAD(P)H Dehydrogenase NDB4 lead to changes in mitochondrial electron transport chain composition, plant growth and response to oxidative stress. Smith C, et al. Plant Cell Physiol, 2011 Jul. PMID 21659327
    2. Arabidopsis genes encoding mitochondrial type II NAD(P)H dehydrogenases have different evolutionary origin and show distinct responses to light. Michalecka AM, et al. Plant Physiol, 2003 Oct. PMID 12972666, Free PMC Article
    3. Galacturonosyltransferase (GAUT)1 and GAUT7 are the core of a plant cell wall pectin biosynthetic homogalacturonan:galacturonosyltransferase complex. Atmodjo MA, et al. Proc Natl Acad Sci U S A, 2011 Dec 13. PMID 22135470, Free PMC Article
    4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altered NDB4 expression affects expression of other genes involved in the alternative respiratory pathway, ROS levels and cellular NAD(P)H activity. nts with altered NDB4 expression show tolerance to salt stress.
      Title: Alterations in the mitochondrial alternative NAD(P)H Dehydrogenase NDB4 lead to changes in mitochondrial electron transport chain composition, plant growth and response to oxidative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127645.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)H dehydrogenase B4
    NP_179673.1
    • NAD(P)H dehydrogenase B4 (NDB4); FUNCTIONS IN: NADH dehydrogenase activity; INVOLVED IN: oxidation reduction; LOCATED IN: extrinsic to mitochondrial inner membrane, mitochondrion, plastid; EXPRESSED IN: 7 plant structures; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), EF-HAND 2 (InterPro:IPR018249); BEST Arabidopsis thaliana protein match is: NAD(P)H dehydrogenase B3 (TAIR:AT4G21490.1); Has 11460 Blast hits to 10815 proteins in 2238 species: Archae - 334; Bacteria - 8988; Metazoa - 48; Fungi - 603; Plants - 426; Viruses - 0; Other Eukaryotes - 1061 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8953057..8955831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127645.4 → NP_179673.1  NAD(P)H dehydrogenase B4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SKT7
      UniProtKB/TrEMBL
      A0A5S9WZQ1, A0A654EW89
      Conserved Domains (2) summary
      PTZ00318
      Location:61 → 582
      PTZ00318; NADH dehydrogenase-like protein; Provisional
      cl21454
      Location:265 → 311
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKT7.1

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