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    SRS Seryl-tRNA synthetase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837734, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRS
    Official Full Name
    Seryl-tRNA synthetase
    Primary source
    TAIR:AT1G11870
    Locus tag
    AT1G11870
    See related
    Araport:AT1G11870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSRS; F12F1.29; F12F1_29; OVA7; ovule abortion 7; Seryl-tRNA synthetase; SERYL-TRNA SYNTHETASE
    Summary
    Seryl-tRNA synthetase targeted to chloroplasts and mitochondria. Its inactivation causes developmental arrest of chloroplasts and mitochondria in Nicotiana benthamiana.
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    Genomic context

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    See SRS in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (4003757..4007015)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycine cleavage T-protein family Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene transferases, transferring hexosyl groups Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase. Kekez M, et al. FEBS J, 2019 Feb. PMID 30570212
    2. Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants. Kim YK, et al. J Biol Chem, 2005 Nov 4. PMID 16107332
    3. Dual targeting is the rule for organellar aminoacyl-tRNA synthetases in Arabidopsis thaliana. Duchêne AM, et al. Proc Natl Acad Sci U S A, 2005 Nov 8. PMID 16251277, Free PMC Article
    4. Requirement of aminoacyl-tRNA synthetases for gametogenesis and embryo development in Arabidopsis. Berg M, et al. Plant J, 2005 Dec. PMID 16297076
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001332005.1
    NM_001332006.1
    NM_001332007.1
    NM_101058.2
    NM_179316.3
    NM_202083.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Seryl-tRNA synthetase
    NP_172651.1
    • Seryl-tRNA synthetase (SRS); FUNCTIONS IN: serine-tRNA ligase activity; INVOLVED IN: chloroplast organization, mitochondrion organization, seryl-tRNA aminoacylation, tRNA aminoacylation, ovule development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: tRNA-binding arm (InterPro:IPR010978), Seryl-tRNA synthetase, class IIa, N-terminal (InterPro:IPR015866), Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain (InterPro:IPR002314), Seryl-tRNA synthetase, class IIa (InterPro:IPR002317), Ubiquitin supergroup (InterPro:IPR019955), Aminoacyl-tRNA synthetase, class II, conserved domain (InterPro:IPR006195), Seryl-tRNA synthetase, class IIa, C-terminal (InterPro:IPR018156); BEST Arabidopsis thaliana protein match is: seryl-tRNA synthetase / serine--tRNA ligase (TAIR:AT5G27470.1); Has 12332 Blast hits to 12318 proteins in 2877 species: Archae - 222; Bacteria - 6777; Metazoa - 382; Fungi - 307; Plants - 156; Viruses - 0; Other Eukaryotes - 4488 (source: NCBI BLink).
    NP_849647.1
    • Seryl-tRNA synthetase (SRS); FUNCTIONS IN: serine-tRNA ligase activity; INVOLVED IN: chloroplast organization, mitochondrion organization, seryl-tRNA aminoacylation, tRNA aminoacylation, ovule development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: tRNA-binding arm (InterPro:IPR010978), Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain (InterPro:IPR002314), Seryl-tRNA synthetase, class IIa, N-terminal (InterPro:IPR015866), Seryl-tRNA synthetase, class IIa (InterPro:IPR002317), Ubiquitin supergroup (InterPro:IPR019955), Aminoacyl-tRNA synthetase, class II, conserved domain (InterPro:IPR006195), Seryl-tRNA synthetase, class IIa, C-terminal (InterPro:IPR018156); BEST Arabidopsis thaliana protein match is: seryl-tRNA synthetase / serine--tRNA ligase (TAIR:AT5G27470.1); Has 12455 Blast hits to 12441 proteins in 2924 species: Archae - 222; Bacteria - 6893; Metazoa - 384; Fungi - 310; Plants - 156; Viruses - 0; Other Eukaryotes - 4490 (source: NCBI BLink).
    NP_973812.1
    • Seryl-tRNA synthetase (SRS); FUNCTIONS IN: serine-tRNA ligase activity; INVOLVED IN: chloroplast organization, mitochondrion organization, seryl-tRNA aminoacylation, tRNA aminoacylation, ovule development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: tRNA-binding arm (InterPro:IPR010978), Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain (InterPro:IPR002314), Seryl-tRNA synthetase, class IIa, N-terminal (InterPro:IPR015866), Seryl-tRNA synthetase, class IIa (InterPro:IPR002317), Ubiquitin supergroup (InterPro:IPR019955), Aminoacyl-tRNA synthetase, class II, conserved domain (InterPro:IPR006195), Seryl-tRNA synthetase, class IIa, C-terminal (InterPro:IPR018156); BEST Arabidopsis thaliana protein match is: seryl-tRNA synthetase / serine--tRNA ligase (TAIR:AT5G27470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4003757..4007015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179316.3 → NP_849647.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IAJ3, O65395, Q8RWT8, Q944K1
      UniProtKB/TrEMBL
      A0A178W4R8, A0A178W5N3
      Conserved Domains (1) summary
      PLN02320
      Location:17 → 514
      PLN02320; seryl-tRNA synthetase

    2. NM_001332005.1 → NP_001321932.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W4R8, A0A1P8ASJ5, A0A5S9TWJ2, A0A654EAK4, A0A7G2DUR8
      Conserved Domains (1) summary
      PLN02320
      Location:17 → 437
      PLN02320; seryl-tRNA synthetase

    3. NM_001332006.1 → NP_001321931.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W4R8, A0A1P8ASF6, A0A5S9TWJ2, A0A654EAK4, A0A7G2DUR8

    4. NM_202083.1 → NP_973812.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IAJ4
      Conserved Domains (2) summary
      pfam02403
      Location:79 → 182
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
      cl00268
      Location:197 → 391
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    5. NM_101058.2 → NP_172651.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W4R8, A0A178W7G5
      Conserved Domains (3) summary
      PLN02320
      Location:17 → 512
      PLN02320; seryl-tRNA synthetase
      cd00770
      Location:195 → 501
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      pfam02403
      Location:77 → 180
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    6. NM_001332007.1 → NP_001321930.1  Seryl-tRNA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASH4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWT8.1

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