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    APA1 aspartic proteinase A1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837740, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APA1
    Official Full Name
    aspartic proteinase A1
    Primary source
    TAIR:AT1G11910
    Locus tag
    AT1G11910
    See related
    Araport:AT1G11910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aspartic proteinase A1; ATAPA1; F12F1.24; F12F1_24
    Summary
    Encodes an aspartic proteinase that forms a heterodimer and is stable over a broad pH range (ph 3-8).
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    Genomic context

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    See APA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (4016712..4021043, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene B-cell receptor-associated protein 31-like protein Neighboring gene wall-associated receptor kinase galacturonan-binding protein Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Arabidopsis aspartic protease APA1 gene confers drought tolerance. Sebastián D, et al. Plant Sci, 2020 Mar. PMID 32005402
    2. Structure-function characterization of the recombinant aspartic proteinase A1 from Arabidopsis thaliana. Mazorra-Manzano MA, et al. Phytochemistry, 2010 Apr. PMID 20079503
    3. Expression and characterization of the recombinant aspartic proteinase A1 from Arabidopsis thaliana. Mazorra-Manzano MA, et al. Phytochemistry, 2008 Oct. PMID 18796341
    4. A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Hackbusch J, et al. Proc Natl Acad Sci U S A, 2005 Mar 29. PMID 15781858, Free PMC Article
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101062.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    aspartic proteinase A1
    NP_172655.1
    • aspartic proteinase A1 (APA1); FUNCTIONS IN: endopeptidase activity; INVOLVED IN: proteolysis, response to salt stress; LOCATED IN: vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Saposin-like (InterPro:IPR011001), Peptidase aspartic (InterPro:IPR021109), Peptidase aspartic, catalytic (InterPro:IPR009007), Saposin-like type B, 1 (InterPro:IPR007856), Saposin-like type B, 2 (InterPro:IPR008138), Saposin B (InterPro:IPR008139), Peptidase A1 (InterPro:IPR001461), Peptidase aspartic, active site (InterPro:IPR001969); BEST Arabidopsis thaliana protein match is: Saposin-like aspartyl protease family protein (TAIR:AT1G62290.2); Has 7443 Blast hits to 5200 proteins in 420 species: Archae - 0; Bacteria - 2; Metazoa - 4134; Fungi - 1703; Plants - 675; Viruses - 0; Other Eukaryotes - 929 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4016712..4021043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332010.1 → NP_001322792.1  aspartic proteinase A1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AV08, A0A5S9TY91, A0A654EA66

    2. NM_101062.4 → NP_172655.1  aspartic proteinase A1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65390, Q38934
      UniProtKB/TrEMBL
      A0A178WAW2, A0A5S9TY91, A0A654EA66
      Conserved Domains (3) summary
      cd06098
      Location:72 → 504
      phytepsin; Phytepsin, a plant homolog of mammalian lysosomal pepsins
      pfam03489
      Location:315 → 348
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:380 → 415
      SapB_1; Saposin-like type B, region 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65390.1

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