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    ABCG12 ABC-2 type transporter family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841575, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCG12
    Official Full Name
    ABC-2 type transporter family protein
    Primary source
    TAIR:AT1G51500
    Locus tag
    AT1G51500
    See related
    Araport:AT1G51500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABC TRANSPORTER FROM THE ABCG SUBFAMILY 12; ARABIDOPSIS THALIANA WHITE-BROWN COMPLEX 12; AtABCG12; ATP-binding cassette G12; ATWBC12; CER5; D3; ECERIFERUM 5; F5D21.6; F5D21_6; WBC12; WHITE-BROWN COMPLEX 12
    Summary
    Encodes an ABC transporter involved in cuticular wax biosynthesis. Lines carrying recessive mutations in this locus have weakly glaucous stem surface, and relative elevated secondary alcohols and ketones.
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    Genomic context

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    See ABCG12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (19097712..19101265, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene disease resistance protein (CC-NBS-LRR class) family protein Neighboring gene beta glucosidase 36 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effects of surface structure mutations in Arabidopsis thaliana on the polarization of reflections from virus-infected leaves. Maxwell DJ, et al. PLoS One, 2017. PMID 28346494, Free PMC Article
    2. Wax and cutin mutants of Arabidopsis: Quantitative characterization of the cuticular transport barrier in relation to chemical composition. Sadler C, et al. Biochim Biophys Acta, 2016 Sep. PMID 26965486
    3. Plant cuticular lipid export requires an ABC transporter. Pighin JA, et al. Science, 2004 Oct 22. PMID 15499022
    4. Cuticular waxes on eceriferum mutants of Arabidopsis thaliana. Rashotte AM, et al. Phytochemistry, 2001 May. PMID 11336252
    5. Arabidopsis ABCG transporters, which are required for export of diverse cuticular lipids, dimerize in different combinations. McFarlane HE, et al. Plant Cell, 2010 Sep. PMID 20870961, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABCG11 and ABCG12 form a heterodimer. ABCG12 trafficking to the plasma membrane is dependent on ABCG11.
      Title: Arabidopsis ABCG transporters, which are required for export of diverse cuticular lipids, dimerize in different combinations.
    2. the CER5 gene encodes an ABC transporter localized in the plasma membrane of epidermal cells; it was concluded that it is required for wax export to the cuticle [CER5]
      Title: Plant cuticular lipid export requires an ABC transporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104028.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in export from cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ABC-2 type transporter family protein
    NP_175561.1
    • ECERIFERUM 5 (CER5); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: wax biosynthetic process; LOCATED IN: membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC-2 type transporter (InterPro:IPR013525), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC-2 type transporter family protein (TAIR:AT3G21090.1); Has 373832 Blast hits to 343583 proteins in 4060 species: Archae - 6936; Bacteria - 298137; Metazoa - 8223; Fungi - 6589; Plants - 5451; Viruses - 9; Other Eukaryotes - 48487 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19097712..19101265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104028.5 → NP_175561.1  ABC-2 type transporter family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C8K2
      UniProtKB/TrEMBL
      A0A178W3S0, A0A5S9WP08, A0A7G2E364
      Conserved Domains (1) summary
      TIGR00955
      Location:40 → 635
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8K2.1

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