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    GIP2 mitotic-spindle organizing 1B-like protein (DUF3743) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843714, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GIP2
    Official Full Name
    mitotic-spindle organizing 1B-like protein (DUF3743)
    Primary source
    TAIR:AT1G73790
    Locus tag
    AT1G73790
    See related
    Araport:AT1G73790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGIP2; F25P22.21; F25P22_21; GCP3-Interacting Protein 1b; GCP3-interacting protein 2; GIP1b
    Summary
    Encodes a gamma-tubulin complex protein that plays a role in gamma-tubulin complex localization, spindle stability and chromosomal segregation.
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    Genomic context

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    See GIP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (27744649..27745429)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene coiled-coil protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Calmodulin binding protein-like protein Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein Neighboring gene Ssu72-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture. Batzenschlager M, et al. Proc Natl Acad Sci U S A, 2015 Jul 14. PMID 26124146, Free PMC Article
    2. Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex. Nakamura M, et al. Plant J, 2012 Jul. PMID 22404201
    3. The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability. Janski N, et al. Plant Cell, 2012 Mar. PMID 22427335, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GIPs are essential for the proper recruitment and/or stabilization of centromeric proteins essential in the specification of the centromere identity, as well as for centromeric cohesion in somatic cells [GIP2]
      Title: Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture.
    2. During mitosis GIPi and GIP2 play a role in gamma-tubulin complex localization, spindle stability and chromosomal segregation.
      Title: The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106038.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CENP-A containing chromatin assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within centromere complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gamma-tubulin complex localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule nucleation by microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of gamma-tubulin ring complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mitotic-spindle organizing 1B-like protein (DUF3743)
    NP_565072.1
    • CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3743 (InterPro:IPR022214); BEST Arabidopsis thaliana protein match is: AtGCP3 interacting protein 1 (TAIR:AT4G09550.1); Has 218 Blast hits to 218 proteins in 98 species: Archae - 0; Bacteria - 0; Metazoa - 56; Fungi - 58; Plants - 72; Viruses - 0; Other Eukaryotes - 32 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27744649..27745429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106038.2 → NP_565072.1  mitotic-spindle organizing 1B-like protein (DUF3743) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C9T3
      UniProtKB/TrEMBL
      A0A178WM34, A0A5S9WU46, A0A654ETU6
      Conserved Domains (1) summary
      pfam12554
      Location:11 → 55
      MOZART1; Mitotic-spindle organizing gamma-tubulin ring associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9T3.1

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