RIN2 RPM1 interacting protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RIN2
Official Full Name: RPM1 interacting protein 2
Primary source: TAIR:AT4G25230
Locus tag: AT4G25230
See related: Araport:AT4G25230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F24A6.70; F24A6_70; RPM1 interacting protein 2
Summary: RPM1 interacting protein 2, has a CUE domain which is sufficient for the interaction with RPM1.Positive regulator of RPM1 and PRS2 mediated hypersensitive response.Functions as ubiquitin ligase and binds to RPM1.
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Genomic context

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See RIN2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 13

Sequence:: Chromosome: 4; NC_003075.7 (12923682..12929274)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
Title: A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341724.1

Supported by ESTs:

NM_118655.4

Supported by ESTs:

NM_179221.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of plant-type hypersensitive response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RPM1 interacting protein 2

NP_194253.2

RPM1 interacting protein 2 (RIN2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), Ubiquitin system component Cue (InterPro:IPR003892); BEST Arabidopsis thaliana protein match is: RPM1 interacting protein 3 (TAIR:AT5G51450.1); Has 2005 Blast hits to 1973 proteins in 236 species: Archae - 0; Bacteria - 2; Metazoa - 699; Fungi - 246; Plants - 674; Viruses - 9; Other Eukaryotes - 375 (source: NCBI BLink).

NP_849552.1

RPM1 interacting protein 2 (RIN2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), Ubiquitin system component Cue (InterPro:IPR003892); BEST Arabidopsis thaliana protein match is: RPM1 interacting protein 3 (TAIR:AT5G51450.1); Has 2005 Blast hits to 1973 proteins in 236 species: Archae - 0; Bacteria - 2; Metazoa - 699; Fungi - 246; Plants - 674; Viruses - 9; Other Eukaryotes - 375 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12923682..12929274

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118655.4 → NP_194253.2 RPM1 interacting protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194253.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A6XER5, Q8VYC8, Q9SB40

UniProtKB/TrEMBL

A0A178UY30

Conserved Domains (3) summary

COG5243
Location:56 → 382

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:336 → 382

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14422
Location:539 → 576

CUE_RIN3_plant; CUE domain found in plant E3 ubiquitin protein ligases RIN2, RIN3 and similar proteins
NM_179221.2 → NP_849552.1 RPM1 interacting protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849552.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6XER5, Q8VYC8, Q9SB40

UniProtKB/TrEMBL

A0A178UY30

Conserved Domains (3) summary

COG5243
Location:56 → 382

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:336 → 382

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14422
Location:539 → 576

CUE_RIN3_plant; CUE domain found in plant E3 ubiquitin protein ligases RIN2, RIN3 and similar proteins
NM_001341724.1 → NP_001328533.1 RPM1 interacting protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A6XER5, Q8VYC8, Q9SB40

UniProtKB/TrEMBL

A0A178UY30