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    BR6OX1 brassinosteroid-6-oxidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833889, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BR6OX1
    Official Full Name
    brassinosteroid-6-oxidase 1
    Primary source
    TAIR:AT5G38970
    Locus tag
    AT5G38970
    See related
    Araport:AT5G38970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBR6OX; BR6OX; BRASSINOSTEROID-6-OXIDASE; brassinosteroid-6-oxidase 1; CYP85A1; K15E6.150; K15E6_150
    Summary
    Encodes a polypeptide involved in the C-6 oxidation of brassinosteroids. Heterologous expression of the protein in yeast conferred the ability to catalyze multiple reactions in which the C-6 position of 6-deoxocastasterone, 6-deoxotyphasterol, 3-dehydro-6-deoxoteasterone and 6-deoxoteasterone are oxidized.
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    Genomic context

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    See BR6OX1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (15594674..15598089, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RmlC-like cupins superfamily protein Neighboring gene RmlC-like cupins superfamily protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP85A1 is required for the initiation of female gametogenesis in Arabidopsis thaliana. Pérez-España VH, et al. Plant Signal Behav, 2011 Mar. PMID 21364326, Free PMC Article
    2. Regulation of transcript levels of the Arabidopsis cytochrome p450 genes involved in brassinosteroid biosynthesis. Bancoş S, et al. Plant Physiol, 2002 Sep. PMID 12226529, Free PMC Article
    3. Light Activates Brassinosteroid Biosynthesis to Promote Hook Opening and Petiole Development in Arabidopsis thaliana. Hamasaki H, et al. Plant Cell Physiol, 2020 Jul 1. PMID 32333772
    4. Unique and overlapping expression patterns of Arabidopsis CYP85 genes involved in brassinosteroid C-6 oxidation. Castle J, et al. Plant Mol Biol, 2005 Jan. PMID 15821873
    5. Brassinosteroid-6-oxidases from Arabidopsis and tomato catalyze multiple C-6 oxidations in brassinosteroid biosynthesis. Shimada Y, et al. Plant Physiol, 2001 Jun. PMID 11402205, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344281.1
    NM_123259.4
    NM_180774.2
    NM_203133.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in brassinosteroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brassinosteroid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within brassinosteroid homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in megagametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    brassinosteroid-6-oxidase 1
    NP_198713.3
    • brassinosteroid-6-oxidase 1 (BR6OX1); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: brassinosteroid-6-oxidase 2 (TAIR:AT3G30180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_851105.1
    • brassinosteroid-6-oxidase 1 (BR6OX1); FUNCTIONS IN: monooxygenase activity, oxygen binding; INVOLVED IN: brassinosteroid homeostasis, brassinosteroid biosynthetic process; LOCATED IN: endomembrane system; EXPRESSED IN: fruit; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: brassinosteroid-6-oxidase 2 (TAIR:AT3G30180.1); Has 28933 Blast hits to 28862 proteins in 1616 species: Archae - 48; Bacteria - 4699; Metazoa - 10231; Fungi - 5134; Plants - 7576; Viruses - 3; Other Eukaryotes - 1242 (source: NCBI BLink).
    NP_974862.1
    • brassinosteroid-6-oxidase 1 (BR6OX1); FUNCTIONS IN: monooxygenase activity, oxygen binding; INVOLVED IN: brassinosteroid homeostasis, brassinosteroid biosynthetic process; LOCATED IN: endomembrane system; EXPRESSED IN: fruit; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403); BEST Arabidopsis thaliana protein match is: brassinosteroid-6-oxidase 2 (TAIR:AT3G30180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      15594674..15598089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180774.2 → NP_851105.1  brassinosteroid-6-oxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FMA5
      UniProtKB/TrEMBL
      A0A5S9Y9K5, A0A654G6C8
      Conserved Domains (1) summary
      PLN02774
      Location:3 → 465
      PLN02774; brassinosteroid-6-oxidase

    2. NM_123259.4 → NP_198713.3  brassinosteroid-6-oxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198713.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAT8
      Conserved Domains (1) summary
      cl12078
      Location:1 → 384
      p450; Cytochrome P450

    3. NM_001344281.1 → NP_001332353.1  brassinosteroid-6-oxidase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAT8

    4. NM_203133.2 → NP_974862.1  brassinosteroid-6-oxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y9K5
      Conserved Domains (1) summary
      cl12078
      Location:3 → 413
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMA5.1

    Gene LinkOut

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