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    ILR3 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835557, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ILR3
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT5G54680
    Locus tag
    AT5G54680
    See related
    Araport:AT5G54680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    basic Helix-Loop-Helix 105; bHLH105; iaa-leucine resistant3; K5F14.2; K5F14_2
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    Genomic context

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    See ILR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (22216934..22219274)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene kinesin 3 Neighboring gene ncRNA Neighboring gene galacturonosyltransferase 12 Neighboring gene Ankyrin repeat family protein Neighboring gene Ankyrin repeat family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional integration of the responses to iron availability in Arabidopsis by the bHLH factor ILR3. Tissot N, et al. New Phytol, 2019 Aug. PMID 30773647
    2. The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis. Samira R, et al. Plant Mol Biol, 2018 Jul. PMID 29882068
    3. Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3. Akmakjian GZ, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34580211, Free PMC Article
    4. The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis. Gao F, et al. Plant Cell, 2020 Feb. PMID 31776233, Free PMC Article
    5. The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response. Aparicio F, et al. Mol Plant Pathol, 2017 Feb. PMID 26929142, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.
      Title: Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.
    2. The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.
      Title: The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.
    3. ILR3 is at the centre of the transcriptional regulatory network that controls iron homeostasis in Arabidopsis.
      Title: Transcriptional integration of the responses to iron availability in Arabidopsis by the bHLH factor ILR3.
    4. The transcription factor IAA-LEUCINE RESISTANT3 (ILR3) regulates iron deficiency response, aliphatic glucosinolate (GLS) biosynthesis and pathogen response.
      Title: The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis.
    5. The AMV CP-ILR3 interaction may down-regulate a host factor, NEET, leading to the activation of plant hormone responses to obtain a hormonal equilibrium state, where infection remains at a level that does not affect plant viability.
      Title: The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response.
    6. bHLH104 and ILR3 play pivotal roles in the regulation of Fe deficiency responses.
      Title: The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124849.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_200279.1
    • iaa-leucine resistant3 (ILR3); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G51070.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22216934..22219274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124849.4 → NP_200279.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LD53, Q9FH37
      UniProtKB/TrEMBL
      A0A178UAU8, A0A5S9YEK5
      Conserved Domains (2) summary
      smart00338
      Location:136 → 170
      BRLZ; basic region leucin zipper
      cd11446
      Location:76 → 151
      bHLH_AtILR3_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FH37.1

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