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    ATRAD17 RADIATION SENSITIVE 17 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836745, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATRAD17
    Official Full Name
    RADIATION SENSITIVE 17
    Primary source
    TAIR:AT5G66130
    Locus tag
    AT5G66130
    See related
    Araport:AT5G66130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K2A18.21; K2A18_21; RAD17; RADIATION SENSITIVE 17
    Summary
    Encodes a homolog to yeast RAD17. Involved in the regulation of DNA damage repair and homologous recombination. Mutant has increased sensitivity to MMS and increased telomere lengths.
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    Genomic context

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    See ATRAD17 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (26433964..26437222)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene winged-helix DNA-binding transcription factor family protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene 3-dehydroquinate synthase Neighboring gene proteasome alpha subunit D2 Neighboring gene Glycosyl hydrolase family 38 protein Neighboring gene receptor homology region transmembrane domain ring H2 motif protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination. Heitzeberg F, et al. Plant J, 2004 Jun. PMID 15165187
    2. Salicylic acid activates DNA damage responses to potentiate plant immunity. Yan S, et al. Mol Cell, 2013 Nov 21. PMID 24207055, Free PMC Article
    3. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345748.1
    NM_126011.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RADIATION SENSITIVE 17
    NP_201414.1
    • RADIATION SENSITIVE 17 (ATRAD17); INVOLVED IN: regulation of DNA repair; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Checkpoint protein Rad24 (InterPro:IPR004582); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT1G77620.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26433964..26437222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126011.2 → NP_201414.1  RADIATION SENSITIVE 17 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MBA3
      UniProtKB/TrEMBL
      A0A178UGK1
      Conserved Domains (2) summary
      cd00882
      Location:136 → 304
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam03215
      Location:91 → 508
      Rad17; Rad17 cell cycle checkpoint protein

    2. NM_001345748.1 → NP_001330043.1  RADIATION SENSITIVE 17 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UGK1, A0A1P8B9K3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MBA3.1

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