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    FY Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831191, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FY
    Official Full Name
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    TAIR:AT5G13480
    Locus tag
    AT5G13480
    See related
    Araport:AT5G13480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T6I14.10; T6I14_10
    Summary
    Encodes a protein with similarity to yeast Pfs2p, an mRNA processing factor. Involved in regulation of flowering time; affects FCA mRNA processing. Homozygous mutants are late flowering, null alleles are embryo lethal.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (4326397..4331971, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ADP/ATP carrier 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Analyses of FY Mutants Reveal Its Role in mRNA Alternative Polyadenylation. Yu Z, et al. Plant Cell, 2019 Oct. PMID 31427469, Free PMC Article
    2. The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype. Jiang S, et al. J Exp Bot, 2012 Apr. PMID 22282534, Free PMC Article
    3. Abscisic acid does not disrupt either the Arabidopsis FCA-FY interaction or its rice counterpart in vitro. Jang YH, et al. Plant Cell Physiol, 2008 Dec. PMID 18854333
    4. A genetic and physiological analysis of late flowering mutants in Arabidopsis thaliana. Koornneef M, et al. Mol Gen Genet, 1991 Sep. PMID 1896021
    5. FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Simpson GG, et al. Cell, 2003 Jun 13. PMID 12809608

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using poly(A) tag sequencing, it was found that >50% of alternative polyadenylation (APA) events are altered in fy single mutants or double mutants with oxt6 (a null mutant of AtCPSF30), but mutation of the FY WD40-repeat has a stronger effect than deletion of the plant-unique Pro-Pro-Leu-Pro-Pro (PPLPP) domain.
      Title: Transcriptome Analyses of FY Mutants Reveal Its Role in mRNA Alternative Polyadenylation.
    2. The PPLPP domains of FY were not essential for the abscisic acid-influenced repression of germination.
      Title: The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype.
    3. These results indicate novel and FCA-independent roles for FY in the regulation of FLC.
      Title: Hypomorphic alleles reveal FCA-independent roles for FY in the regulation of FLOWERING LOCUS C.
    4. FCA interaction with FY mediates changes in FCA transcript processing.
      Title: Additional targets of the Arabidopsis autonomous pathway members, FCA and FY.
    5. The expression domain of FY supports its roles in essential and flowering-time functions; FY may mediate both regulated and constitutive RNA 3'-end processing [FY]
      Title: An allelic series reveals essential roles for FY in plant development in addition to flowering-time control.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343274.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_001318555.1
    • FY; FUNCTIONS IN: protein binding; INVOLVED IN: mRNA processing, regulation of flower development, embryo development ending in seed dormancy; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781), G-protein beta WD-40 repeat, region (InterPro:IPR020472); BEST Arabidopsis thaliana protein match is: pleiotropic regulatory locus 1 (TAIR:AT4G15900.1).
    NP_196852.3
    • FY; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: pleiotropic regulatory locus 1 (TAIR:AT4G15900.1); Has 97899 Blast hits to 44472 proteins in 1019 species: Archae - 62; Bacteria - 9446; Metazoa - 41432; Fungi - 21528; Plants - 12338; Viruses - 53; Other Eukaryotes - 13040 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4326397..4331971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343276.1 → NP_001331011.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U808, A0A1P8BCJ2

    2. NM_001343275.1 → NP_001331012.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U808, A0A1P8BCM2

    3. NM_121351.5 → NP_196852.3  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196852.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NLV4, Q9FY53
      UniProtKB/TrEMBL
      A0A178U808, A0A5S9Y4D0, A0A654G0Q6
      Conserved Domains (2) summary
      cd00200
      Location:123 → 404
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:129 → 163
      7WD40; WD40 repeat [structural motif]

    4. NM_001343274.1 → NP_001318555.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U808, F4K3Y7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NLV4.1

    Gene LinkOut

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