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    GolS2 galactinol synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842114, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GolS2
    Official Full Name
    galactinol synthase 2
    Primary source
    TAIR:AT1G56600
    Locus tag
    AT1G56600
    See related
    Araport:AT1G56600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGolS2; F25P12.95; F25P12_95; galactinol synthase 2
    Summary
    GolS2 is a galactinol synthase that catalyzes the formation of galactinol from UDP-galactose and myo-inositol. GolS2 transcript levels rise in response to methyl viologen, an oxidative damage-inducing agent. Plants over-expressing GolS2 have increased tolerance to salt, chilling, and high-light stress.
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    Genomic context

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    See GolS2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (21207537..21209635)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene plant/protein (Protein of unknown function, DUF538) Neighboring gene Clathrin adaptor complexes medium subunit family protein Neighboring gene pseudo Neighboring gene Protein with RNI-like/FBD-like domain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis galactinol synthase AtGolS2 improves drought tolerance in the monocot model Brachypodium distachyon. Himuro Y, et al. J Plant Physiol, 2014 Aug 15. PMID 24973584
    2. Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis. Song C, et al. Mol Cells, 2016 Jun 30. PMID 27109422, Free PMC Article
    3. Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana. Taji T, et al. Plant J, 2002 Feb. PMID 11846875
    4. Metabolic pathways involved in cold acclimation identified by integrated analysis of metabolites and transcripts regulated by DREB1A and DREB2A. Maruyama K, et al. Plant Physiol, 2009 Aug. PMID 19502356, Free PMC Article
    5. Galactinol and raffinose constitute a novel function to protect plants from oxidative damage. Nishizawa A, et al. Plant Physiol, 2008 Jul. PMID 18502973, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings provide evidence that GolS1 and GolS2 are directly regulated by HsfA3 and that GolS enzymes play an important role in improving oxidative stress tolerance by increasing galactinol biosynthesis in Arabidopsis.
      Title: Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
    2. AtGolS2 can confer drought tolerance to monocots.
      Title: Arabidopsis galactinol synthase AtGolS2 improves drought tolerance in the monocot model Brachypodium distachyon.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_104537.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol 3-alpha-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within galactose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    galactinol synthase 2
    NP_176053.1
    • galactinol synthase 2 (GolS2); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 8 (InterPro:IPR002495); BEST Arabidopsis thaliana protein match is: galactinol synthase 3 (TAIR:AT1G09350.1); Has 1296 Blast hits to 1295 proteins in 304 species: Archae - 0; Bacteria - 134; Metazoa - 258; Fungi - 290; Plants - 471; Viruses - 73; Other Eukaryotes - 70 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21207537..21209635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104537.3 → NP_176053.1  galactinol synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q945L1, Q9FXB2
      UniProtKB/TrEMBL
      A0A5S9WS80, A0A654EJ40, W8Q3N9
      Conserved Domains (1) summary
      PLN00176
      Location:1 → 335
      PLN00176; galactinol synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FXB2.1

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