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    GAE4 UDP-D-glucuronate 4-epimerase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819139, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAE4
    Official Full Name
    UDP-D-glucuronate 4-epimerase 4
    Primary source
    TAIR:AT2G45310
    Locus tag
    AT2G45310
    See related
    Araport:AT2G45310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4L23.18; UDP-D-glucuronate 4-epimerase 4
    Summary
    UDP-D-glucuronate 4-epimerase
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    Genomic context

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    See GAE4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (18682081..18684042)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Transketolase Neighboring gene RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta Neighboring gene ncRNA Neighboring gene polyphosphatidylinositol phosphatase Neighboring gene RNA 2'-phosphotransferase, Tpt1 / KptA family Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biosynthesis of UDP-galacturonic acid in plants. Functional cloning and characterization of Arabidopsis UDP-D-glucuronic acid 4-epimerase. Gu X, et al. Plant Physiol, 2004 Dec. PMID 15563616, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional cloning of the gene and biochemical characterization of the encoded enzyme.
      Title: The biosynthesis of UDP-galacturonic acid in plants. Functional cloning and characterization of Arabidopsis UDP-D-glucuronic acid 4-epimerase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_130094.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucuronate 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    UDP-D-glucuronate 4-epimerase 4
    NP_182056.1
    • UDP-D-glucuronate 4-epimerase 4 (GAE4); FUNCTIONS IN: coenzyme binding, racemase and epimerase activity, acting on carbohydrates and derivatives, binding, catalytic activity; INVOLVED IN: cellular metabolic process, carbohydrate metabolic process, nucleotide-sugar metabolic process, metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), Nucleotide sugar epimerase (InterPro:IPR008089); BEST Arabidopsis thaliana protein match is: UDP-D-glucuronate 4-epimerase 3 (TAIR:AT4G00110.1); Has 44632 Blast hits to 44622 proteins in 2990 species: Archae - 813; Bacteria - 26318; Metazoa - 807; Fungi - 418; Plants - 1224; Viruses - 43; Other Eukaryotes - 15009 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18682081..18684042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130094.2 → NP_182056.1  UDP-D-glucuronate 4-epimerase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22141
      UniProtKB/TrEMBL
      A0A178VSI0, A0A5S9X7G5
      Conserved Domains (2) summary
      cd05253
      Location:97 → 427
      UDP_GE_SDE_e; UDP glucuronic acid epimerase, extended (e) SDRs
      COG0451
      Location:99 → 428
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22141.1

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