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    Sult1c2a sulfotransferase family 1C member 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sult1c2aprovided by RGD
    Official Full Name
    sulfotransferase family 1C member 2Aprovided by RGD
    Primary source
    RGD:1305885
    See related
    EnsemblRapid:ENSRNOG00000042111 AllianceGenome:RGD:1305885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST1C2A; Sult1c1; RGD1562392; RGD1565421
    Summary
    Enables aryl sulfotransferase activity. Involved in sulfation. Located in lysosome. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 6322.9) See more
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    Genomic context

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    See Sult1c2a in Genome Data Viewer
    Location:
    9q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (7075873..7103316, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6873697..6904736, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4152588..4168355, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932415M13 gene like Neighboring gene sulfotransferase 1C2-like Neighboring gene brain acid soluble protein 1-like Neighboring gene sulfotransferase 1C2A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic properties, tissue-specific expression, and lysosomal location of two highly homologous rat SULT1C2 sulfotransferases. Xiangrong L, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872834
    2. Expression of the sulfotransferase 1C family: implications for xenobiotic toxicity. Runge-Morris M, et al. Drug Metab Rev, 2013 Nov. PMID 24028175
    3. Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. Senggunprai L, et al. Biochem J, 2009 Aug 27. PMID 19548878
    4. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Brand W, et al. Drug Metab Dispos, 2010 Apr. PMID 20056724
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108549

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aryl sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1C2A
    Names
    rSULT1C2A
    sulfotransferase 1C2
    sulfotransferase K2
    sulfotransferase K2-like
    sulfotransferase family, cytosolic, 1C, member 1
    sulfotransferase family, cytosolic, 1C, member 2a
    XP_038939397.2
    XP_038939398.2
    XP_038939399.2
    XP_038939400.2
    XP_063123137.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013177.3 → NP_001013195.3  sulfotransferase 1C2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9

    2. NM_001428986.1 → NP_001415915.1  sulfotransferase 1C2A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9

    3. NM_001428987.1 → NP_001415916.1  sulfotransferase 1C2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9

    4. NM_001428988.1 → NP_001415917.1  sulfotransferase 1C2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      7075873..7103316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083469.2 → XP_038939397.2  sulfotransferase 1C2A isoform X1

    2. XM_039083471.2 → XP_038939399.2  sulfotransferase 1C2A isoform X1

      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9
      Related
      ENSRNOP00000096879.2, ENSRNOT00000106188.2

    3. XM_039083470.2 → XP_038939398.2  sulfotransferase 1C2A isoform X1

      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9

    4. XM_039083472.2 → XP_038939400.2  sulfotransferase 1C2A isoform X2

      Related
      ENSRNOP00000058577.6, ENSRNOT00000061861.6

    5. XM_063267067.1 → XP_063123137.1  sulfotransferase 1C2A isoform X2

      UniProtKB/Swiss-Prot
      Q569D0, Q642G8, Q9WUW9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUW9.2 GenPept UniProtKB/Swiss-Prot:Q9WUW9

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