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    NEK11 NIMA related kinase 11 [ Homo sapiens (human) ]

    Gene ID: 79858, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NEK11provided by HGNC
    Official Full Name
    NIMA related kinase 11provided by HGNC
    Primary source
    HGNC:HGNC:18593
    See related
    Ensembl:ENSG00000114670 MIM:609779; AllianceGenome:HGNC:18593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
    Expression
    Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.7) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEK11 in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (131026877..131350465)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (133770580..134094242)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130745721..131069309)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:130761319-130762129 Neighboring gene uncharacterized LOC124909434 Neighboring gene asteroid homolog 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:130796655-130797231 Neighboring gene RNA, U6 small nuclear 726, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:130935591-130936092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131050541-131051088 Neighboring gene NUDT16 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131080535-131081079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131100488-131101057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131101058-131101626 Neighboring gene nudix hydrolase 16 like 2, pseudogene Neighboring gene nudix hydrolase 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NEK11 as a candidate high-penetrance melanoma susceptibility gene. Christodoulou E, et al. J Med Genet, 2020 Mar. PMID 31704778
    2. Never say never. The NIMA-related protein kinases in mitotic control. O'Connell MJ, et al. Trends Cell Biol, 2003 May. PMID 12742165
    3. Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents. Sabir SR, et al. PLoS One, 2015. PMID 26501353, Free PMC Article
    4. Cell cycle regulation by the NEK family of protein kinases. Fry AM, et al. J Cell Sci, 2012 Oct 1. PMID 23132929, Free PMC Article
    5. Downregulation of NEK11 is associated with drug resistance in ovarian cancer. Liu X, et al. Int J Oncol, 2014 Sep. PMID 24969318

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEK11 as a candidate high-penetrance melanoma susceptibility gene.
      Title: NEK11 as a candidate high-penetrance melanoma susceptibility gene.
    2. Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.
      Title: Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.
    3. contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage
      Title: Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.
    4. Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer.
      Title: Downregulation of NEK11 is associated with drug resistance in ovarian cancer.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation.
      Title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
    7. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
    8. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
      Title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
    9. Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway
      Title: Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.
    10. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
      Title: Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23495

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek11
    Names
    NIMA (never in mitosis gene a)- related kinase 11
    NP_001139475.1
    NP_001308149.1
    NP_001308150.1
    NP_001308151.1
    NP_001308152.1
    NP_001308153.1
    NP_001339951.1
    NP_001339952.1
    NP_001339953.1
    NP_001339954.1
    NP_001339955.1
    NP_001339956.1
    NP_001339957.1
    NP_001339958.1
    NP_001339959.1
    NP_001339960.1
    NP_001339961.1
    NP_001339962.1
    NP_001339963.1
    NP_001339965.1
    NP_001339966.1
    NP_001339967.1
    NP_001339968.1
    NP_001339969.1
    NP_001339970.1
    NP_001339971.1
    NP_001339972.1
    NP_001339973.1
    NP_001339974.1
    NP_001339975.1
    NP_001339977.1
    NP_079076.3
    NP_665917.1
    XP_011511476.1
    XP_011511477.1
    XP_016862695.1
    XP_016862696.1
    XP_016862697.1
    XP_016862698.1
    XP_016862699.1
    XP_016862709.1
    XP_016862710.1
    XP_016862711.1
    XP_016862717.1
    XP_024309524.1
    XP_024309528.1
    XP_047304924.1
    XP_047304926.1
    XP_047304927.1
    XP_047304928.1
    XP_047304929.1
    XP_047304930.1
    XP_047304932.1
    XP_047304933.1
    XP_047304934.1
    XP_047304935.1
    XP_047304936.1
    XP_054203894.1
    XP_054203895.1
    XP_054203896.1
    XP_054203897.1
    XP_054203898.1
    XP_054203899.1
    XP_054203900.1
    XP_054203901.1
    XP_054203902.1
    XP_054203903.1
    XP_054203904.1
    XP_054203905.1
    XP_054203906.1
    XP_054203907.1
    XP_054203908.1
    XP_054203909.1
    XP_054203910.1
    XP_054203911.1
    XP_054203912.1
    XP_054203913.1
    XP_054203914.1
    XP_054203915.1
    XP_054203916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029225.1 RefSeqGene

      Range
      5028..328616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001146003.2 → NP_001139475.1  serine/threonine-protein kinase Nek11 isoform 3

      See identical proteins and their annotated locations for NP_001139475.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB071996, AK297300, AL833472, BX328072
      Consensus CDS
      CCDS54639.1
      UniProtKB/Swiss-Prot
      Q8NG66
      UniProtKB/TrEMBL
      B4DM56
      Related
      ENSP00000423458.1, ENST00000510688.5
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    2. NM_001321220.2 → NP_001308149.1  serine/threonine-protein kinase Nek11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB071996, AK027148, AK297300, AL833472, BX328072
      Consensus CDS
      CCDS3069.1
      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
      UniProtKB/TrEMBL
      B7ZAN7
      Related
      ENSP00000421851.1, ENST00000508196.5
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    3. NM_001321221.2 → NP_001308150.1  serine/threonine-protein kinase Nek11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AB071996, AC116424, AK027148, AK297300, AL833472, BI032921, BX328072
      UniProtKB/Swiss-Prot
      Q8NG66
      UniProtKB/TrEMBL
      B4DM56
      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    4. NM_001321222.2 → NP_001308151.1  serine/threonine-protein kinase Nek11 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AB071996, AK027148, AK297300, AL833472, BX328072
      Consensus CDS
      CCDS82837.1
      UniProtKB/TrEMBL
      B7ZAN7, E9PHI8
      Related
      ENSP00000421549.1, ENST00000510769.5
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001321223.1 → NP_001308152.1  serine/threonine-protein kinase Nek11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      BC028587, DB446413
      Consensus CDS
      CCDS82836.1
      UniProtKB/Swiss-Prot
      Q8NG66
      Related
      ENSP00000426662.1, ENST00000507910.5
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    6. NM_001321224.2 → NP_001308153.1  serine/threonine-protein kinase Nek11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AB071996, AK027148, AK293261, AK297300, AL833472
      UniProtKB/TrEMBL
      B4DDN2
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001353022.2 → NP_001339951.1  serine/threonine-protein kinase Nek11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    8. NM_001353023.2 → NP_001339952.1  serine/threonine-protein kinase Nek11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Consensus CDS
      CCDS3069.1
      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
      UniProtKB/TrEMBL
      B7ZAN7
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    9. NM_001353024.2 → NP_001339953.1  serine/threonine-protein kinase Nek11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B7ZAN7
      Conserved Domains (1) summary
      cd08222
      Location:28 → 286
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    10. NM_001353025.2 → NP_001339954.1  serine/threonine-protein kinase Nek11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B7ZAN7
      Conserved Domains (1) summary
      cd08222
      Location:28 → 286
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    11. NM_001353026.2 → NP_001339955.1  serine/threonine-protein kinase Nek11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    12. NM_001353027.2 → NP_001339956.1  serine/threonine-protein kinase Nek11 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B7ZAN7
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    13. NM_001353028.2 → NP_001339957.1  serine/threonine-protein kinase Nek11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Consensus CDS
      CCDS54639.1
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    14. NM_001353029.2 → NP_001339958.1  serine/threonine-protein kinase Nek11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Consensus CDS
      CCDS54639.1
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    15. NM_001353030.2 → NP_001339959.1  serine/threonine-protein kinase Nek11 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    16. NM_001353031.2 → NP_001339960.1  serine/threonine-protein kinase Nek11 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    17. NM_001353032.2 → NP_001339961.1  serine/threonine-protein kinase Nek11 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Consensus CDS
      CCDS82837.1
      UniProtKB/TrEMBL
      B7ZAN7, E9PHI8
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    18. NM_001353033.2 → NP_001339962.1  serine/threonine-protein kinase Nek11 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:7 → 181
      PKc_like; Protein Kinases, catalytic domain

    19. NM_001353034.2 → NP_001339963.1  serine/threonine-protein kinase Nek11 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:7 → 181
      PKc_like; Protein Kinases, catalytic domain

    20. NM_001353036.2 → NP_001339965.1  serine/threonine-protein kinase Nek11 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563

    21. NM_001353037.2 → NP_001339966.1  serine/threonine-protein kinase Nek11 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B7ZAN7
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    22. NM_001353038.2 → NP_001339967.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    23. NM_001353039.2 → NP_001339968.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    24. NM_001353040.2 → NP_001339969.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    25. NM_001353041.2 → NP_001339970.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    26. NM_001353042.2 → NP_001339971.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    27. NM_001353043.2 → NP_001339972.1  serine/threonine-protein kinase Nek11 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    28. NM_001353044.2 → NP_001339973.1  serine/threonine-protein kinase Nek11 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B4DM56, B7ZAN7
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    29. NM_001353045.2 → NP_001339974.1  serine/threonine-protein kinase Nek11 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      UniProtKB/TrEMBL
      B4DM56, B7ZAN7
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    30. NM_001353046.2 → NP_001339975.1  serine/threonine-protein kinase Nek11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC121332, CK903563
      UniProtKB/TrEMBL
      B4DDN2
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    31. NM_001353048.2 → NP_001339977.1  serine/threonine-protein kinase Nek11 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    32. NM_024800.5 → NP_079076.3  serine/threonine-protein kinase Nek11 isoform 1

      See identical proteins and their annotated locations for NP_079076.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1), also known as NEK11L.
      Source sequence(s)
      AB071996, AK297300, AL833472, BX328072
      Consensus CDS
      CCDS3069.1
      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
      UniProtKB/TrEMBL
      B7ZAN7
      Related
      ENSP00000372857.4, ENST00000383366.9
      Conserved Domains (1) summary
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    33. NM_145910.4 → NP_665917.1  serine/threonine-protein kinase Nek11 isoform 2

      See identical proteins and their annotated locations for NP_665917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), also known as NEK11S, is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB071997, AK297300, BU674219
      Consensus CDS
      CCDS46915.1
      UniProtKB/Swiss-Prot
      Q8NG66
      UniProtKB/TrEMBL
      B4DM56
      Related
      ENSP00000425114.1, ENST00000511262.5
      Conserved Domains (2) summary
      smart00220
      Location:29 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08222
      Location:28 → 287
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      131026877..131350465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007209.2 → XP_016862698.1  serine/threonine-protein kinase Nek11 isoform X1

      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    2. XM_047448971.1 → XP_047304927.1  serine/threonine-protein kinase Nek11 isoform X3

      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

    3. XM_017007206.2 → XP_016862695.1  serine/threonine-protein kinase Nek11 isoform X1

      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    4. XM_047448970.1 → XP_047304926.1  serine/threonine-protein kinase Nek11 isoform X3

      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

    5. XM_047448972.1 → XP_047304928.1  serine/threonine-protein kinase Nek11 isoform X3

      UniProtKB/Swiss-Prot
      A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

    6. XM_047448974.1 → XP_047304930.1  serine/threonine-protein kinase Nek11 isoform X5

    7. XM_024453756.2 → XP_024309524.1  serine/threonine-protein kinase Nek11 isoform X6

      UniProtKB/TrEMBL
      B7ZAN7, E9PHI8
      Conserved Domains (1) summary
      cl21453
      Location:28 → 216
      PKc_like; Protein Kinases, catalytic domain

    8. XM_047448977.1 → XP_047304933.1  serine/threonine-protein kinase Nek11 isoform X11

    9. XM_017007208.2 → XP_016862697.1  serine/threonine-protein kinase Nek11 isoform X1

      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    10. XM_047448968.1 → XP_047304924.1  serine/threonine-protein kinase Nek11 isoform X2

    11. XM_047448973.1 → XP_047304929.1  serine/threonine-protein kinase Nek11 isoform X4

    12. XM_047448976.1 → XP_047304932.1  serine/threonine-protein kinase Nek11 isoform X11

    13. XM_047448980.1 → XP_047304936.1  serine/threonine-protein kinase Nek11 isoform X15

    14. XM_017007221.2 → XP_016862710.1  serine/threonine-protein kinase Nek11 isoform X8

    15. XM_017007220.2 → XP_016862709.1  serine/threonine-protein kinase Nek11 isoform X7

    16. XM_047448978.1 → XP_047304934.1  serine/threonine-protein kinase Nek11 isoform X12

    17. XM_017007222.2 → XP_016862711.1  serine/threonine-protein kinase Nek11 isoform X9

    18. XM_047448979.1 → XP_047304935.1  serine/threonine-protein kinase Nek11 isoform X13

      Related
      ENSP00000349389.5, ENST00000356918.8

    19. XM_017007210.2 → XP_016862699.1  serine/threonine-protein kinase Nek11 isoform X1

      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    20. XM_017007207.2 → XP_016862696.1  serine/threonine-protein kinase Nek11 isoform X1

      Conserved Domains (1) summary
      cd08222
      Location:28 → 329
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    21. XM_011513174.2 → XP_011511476.1  serine/threonine-protein kinase Nek11 isoform X10

      See identical proteins and their annotated locations for XP_011511476.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    22. XM_011513175.2 → XP_011511477.1  serine/threonine-protein kinase Nek11 isoform X10

      See identical proteins and their annotated locations for XP_011511477.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    23. XM_017007228.2 → XP_016862717.1  serine/threonine-protein kinase Nek11 isoform X10

      Conserved Domains (1) summary
      cl21453
      Location:1 → 139
      PKc_like; Protein Kinases, catalytic domain

    24. XM_024453760.2 → XP_024309528.1  serine/threonine-protein kinase Nek11 isoform X14

      Conserved Domains (2) summary
      cl21453
      Location:1 → 105
      PKc_like; Protein Kinases, catalytic domain
      cl25539
      Location:16 → 223
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001740271.2 RNA Sequence

      Related
      ENST00000514915.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      133770580..134094242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347920.1 → XP_054203895.1  serine/threonine-protein kinase Nek11 isoform X1

    2. XM_054347925.1 → XP_054203900.1  serine/threonine-protein kinase Nek11 isoform X3

    3. XM_054347927.1 → XP_054203902.1  serine/threonine-protein kinase Nek11 isoform X3

    4. XM_054347929.1 → XP_054203904.1  serine/threonine-protein kinase Nek11 isoform X5

    5. XM_054347930.1 → XP_054203905.1  serine/threonine-protein kinase Nek11 isoform X6

    6. XM_054347937.1 → XP_054203912.1  serine/threonine-protein kinase Nek11 isoform X11

    7. XM_054347922.1 → XP_054203897.1  serine/threonine-protein kinase Nek11 isoform X1

    8. XM_054347926.1 → XP_054203901.1  serine/threonine-protein kinase Nek11 isoform X3

    9. XM_054347919.1 → XP_054203894.1  serine/threonine-protein kinase Nek11 isoform X1

    10. XM_054347924.1 → XP_054203899.1  serine/threonine-protein kinase Nek11 isoform X2

    11. XM_054347928.1 → XP_054203903.1  serine/threonine-protein kinase Nek11 isoform X4

    12. XM_054347936.1 → XP_054203911.1  serine/threonine-protein kinase Nek11 isoform X11

    13. XM_054347941.1 → XP_054203916.1  serine/threonine-protein kinase Nek11 isoform X15

    14. XM_054347932.1 → XP_054203907.1  serine/threonine-protein kinase Nek11 isoform X8

    15. XM_054347931.1 → XP_054203906.1  serine/threonine-protein kinase Nek11 isoform X7

    16. XM_054347938.1 → XP_054203913.1  serine/threonine-protein kinase Nek11 isoform X12

    17. XM_054347933.1 → XP_054203908.1  serine/threonine-protein kinase Nek11 isoform X9

    18. XM_054347939.1 → XP_054203914.1  serine/threonine-protein kinase Nek11 isoform X13

    19. XM_054347923.1 → XP_054203898.1  serine/threonine-protein kinase Nek11 isoform X1

    20. XM_054347921.1 → XP_054203896.1  serine/threonine-protein kinase Nek11 isoform X1

    21. XM_054347934.1 → XP_054203909.1  serine/threonine-protein kinase Nek11 isoform X10

    22. XM_054347935.1 → XP_054203910.1  serine/threonine-protein kinase Nek11 isoform X10

    23. XM_054347940.1 → XP_054203915.1  serine/threonine-protein kinase Nek11 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NG66.2 GenPept UniProtKB/Swiss-Prot:Q8NG66

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