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    LRRC1 leucine rich repeat containing 1 [ Homo sapiens (human) ]

    Gene ID: 55227, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LRRC1provided by HGNC
    Official Full Name
    leucine rich repeat containing 1provided by HGNC
    Primary source
    HGNC:HGNC:14307
    See related
    Ensembl:ENSG00000137269 MIM:608195; AllianceGenome:HGNC:14307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LANO; dJ523E19.1
    Summary
    Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon (RPKM 4.5), thyroid (RPKM 3.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC1 in Genome Data Viewer
    Location:
    6p12.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53795005..53924125)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (53634953..53764073)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (53659803..53788923)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24700 Neighboring gene Sharpr-MPRA regulatory region 11274 Neighboring gene kelch like family member 31 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:53587553-53587738 Neighboring gene uncharacterized LOC124901334 Neighboring gene NANOG hESC enhancer GRCh37_chr6:53595032-53595549 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:53599001-53600200 Neighboring gene uncharacterized LOC124901333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17294 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53659875-53660587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17295 Neighboring gene Sharpr-MPRA regulatory region 10889 Neighboring gene Sharpr-MPRA regulatory region 6720 Neighboring gene uncharacterized LOC101927189 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53810369-53810988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53810989-53811607 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:53826656-53827156 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:53841998-53842202 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:53848425-53849624 Neighboring gene MLIP intronic transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling. Lopez Almeida L, et al. Stem Cell Reports, 2018 Nov 13. PMID 30344009, Free PMC Article
    2. The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation. Wang X, et al. Mol Cell Biochem, 2023 Jul. PMID 36370237, Free PMC Article
    3. Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1. Wu H, et al. Cell Death Dis, 2020 Sep 25. PMID 32978367, Free PMC Article
    4. Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma. Li Y, et al. Mol Biol Rep, 2013 Jul. PMID 23645086
    5. LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling. Wang Y, et al. J Mol Histol, 2024 Feb. PMID 38165568

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
      Title: The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
    2. LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating beta-catenin/c-Myc signaling.
      Title: LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling.
    3. The downstream PPARgamma target LRRC1 participates in early stage adipocytic differentiation.
      Title: The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation.
    4. Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1.
      Title: Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1.
    5. Common and specific sets of proteins associated to SCRIB and LANO by MS are identified and an extensive landscape of their associated networks and the first comparative analysis of their respective interactomes are provided
      Title: The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β-Catenin Signaling Pathway.
    6. Lano/LRRC1-depleted cells secrete increased levels of WNT ligands.
      Title: The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling.
    7. LRRC1 contributes to HCC development, and may be a potential target for therapeutic intervention in this disease.
      Title: Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10775, FLJ11834

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 1
    Names
    LANO adapter protein
    LAP (leucine-rich repeats and PDZ) and no PDZ protein
    LAP and no PDZ protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018214.5 → NP_060684.4  leucine-rich repeat-containing protein 1

      See identical proteins and their annotated locations for NP_060684.4

      Status: VALIDATED

      Source sequence(s)
      AL033384, BC003193
      Consensus CDS
      CCDS4953.2
      UniProtKB/Swiss-Prot
      Q5TGN3, Q9BTT6, Q9HAC0, Q9NVF1
      UniProtKB/TrEMBL
      A8K883
      Related
      ENSP00000359925.1, ENST00000370888.6
      Conserved Domains (3) summary
      cd00116
      Location:33 → 232
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:129 → 186
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      53795005..53924125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010997.2 → XP_016866486.1  leucine-rich repeat-containing protein 1 isoform X2

    2. XM_011514727.3 → XP_011513029.1  leucine-rich repeat-containing protein 1 isoform X1

      Conserved Domains (2) summary
      sd00033
      Location:48 → 70
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:70 → 127
      LRR_8; Leucine rich repeat

    RNA

    1. XR_007059279.1 RNA Sequence

    2. XR_001743505.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      53634953..53764073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355779.1 → XP_054211754.1  leucine-rich repeat-containing protein 1 isoform X2

    2. XM_054355778.1 → XP_054211753.1  leucine-rich repeat-containing protein 1 isoform X1

    RNA

    1. XR_008487363.1 RNA Sequence

    2. XR_008487364.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025168.1: Suppressed sequence

      Description
      NM_025168.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BTT6.1 GenPept UniProtKB/Swiss-Prot:Q9BTT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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