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    EIF3I eukaryotic translation initiation factor 3 subunit I [ Homo sapiens (human) ]

    Gene ID: 8668, updated on 9-Dec-2024

    Summary

    Official Symbol
    EIF3Iprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Iprovided by HGNC
    Primary source
    HGNC:HGNC:3272
    See related
    Ensembl:ENSG00000084623 MIM:603911; AllianceGenome:HGNC:3272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EIF3I in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32222407..32236170)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32080311..32094075)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32688008..32701771)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene IQ motif containing C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene doublecortin domain containing 2B Neighboring gene transmembrane protein 234 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:32687227-32688426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32698370-32698870 Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 681 Neighboring gene family with sequence similarity 167 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 684 Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 590

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit I (EIF3I) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit I (EIF3I), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit I
    Names
    TGF-beta receptor-interacting protein 1
    TGFbeta receptor-interacting protein 1
    eukaryotic translation initiation factor 3 subunit 2
    eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
    eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa
    predicted protein of HQ2242

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394168.1NP_001381097.1  eukaryotic translation initiation factor 3 subunit I isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL121991
      Consensus CDS
      CCDS90907.1
      UniProtKB/TrEMBL
      A0A7I2YQI2, A0A7I2YQI6
      Related
      ENSP00000503706.1, ENST00000678063.1
      Conserved Domains (2) summary
      sd00039
      Location:1450
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:6299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_003757.4NP_003748.1  eukaryotic translation initiation factor 3 subunit I isoform 1

      See identical proteins and their annotated locations for NP_003748.1

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL121991
      Consensus CDS
      CCDS357.1
      UniProtKB/Swiss-Prot
      Q13347
      UniProtKB/TrEMBL
      A0A7P0MRT9, Q53HU7, Q5U0F4
      Related
      ENSP00000504061.1, ENST00000677711.2
      Conserved Domains (2) summary
      sd00039
      Location:1450
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:6311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32222407..32236170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450518.2XP_024306286.1  eukaryotic translation initiation factor 3 subunit I isoform X1

      Related
      ENST00000676957.1
      Conserved Domains (2) summary
      sd00039
      Location:5894
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:34178
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32080311..32094075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339351.1XP_054195326.1  eukaryotic translation initiation factor 3 subunit I isoform X1