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    ROR1-AS1 ROR1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 101927034, updated on 12-Nov-2024

    Summary

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    Official Symbol
    ROR1-AS1provided by HGNC
    Official Full Name
    ROR1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:40508
    See related
    Ensembl:ENSG00000223949 AllianceGenome:HGNC:40508
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 1.4) See more
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    Genomic context

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    See ROR1-AS1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (64094442..64113791, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63970220..63989553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64560125..64579474, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene receptor tyrosine kinase like orphan receptor 1 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:64620864-64621414 Neighboring gene uncharacterized LOC105378773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64661738-64662238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64662239-64662739 Neighboring gene Sharpr-MPRA regulatory region 11272 Neighboring gene ubiquitin conjugating enzyme E2 U Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:64728314-64729513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells. Li X, et al. BMC Cancer, 2023 Sep 28. PMID 37770853, Free PMC Article
    2. LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504. Wu X, et al. Aging (Albany NY), 2020 Dec 19. PMID 33401251, Free PMC Article
    3. Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p. Zhang L, et al. J Recept Signal Transduct Res, 2021 Dec. PMID 33081599
    4. LncRNA ROR1‑AS1 high expression and its prognostic significance in liver cancer. Zhang Z, et al. Oncol Rep, 2020 Jan. PMID 31746401, Free PMC Article
    5. Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375. Xu N, et al. J BUON, 2019 Nov-Dec. PMID 31983094

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis.
      Title: Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis.
    2. ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
      Title: ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
    3. Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
      Title: Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
    4. ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
      Title: ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
    5. LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
      Title: LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
    6. Results suggested that ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC.
      Title: Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375.
    7. Data found that expression of lncRNA ROR1AS1 was significantly increased in hepatocellular carcinoma (HCC) patients and associated with several clinical features and an undesirable prognosis; therefore, lncRNA ROR1AS1 may serve as a useful biomarker for the prognosis of patients with HCC.
      Title: LncRNA ROR1‑AS1 high expression and its prognostic significance in liver cancer.
    8. ROR1-AS1 directly bound with miR-504 and act as a molecular sponge to decrease miR-504 expression. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis.
      Title: Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • THE1B/ROR1-AS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110665.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK096291, AL445205

    2. NR_110666.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' and 3' structure and is shorter compared to variant 1.
      Source sequence(s)
      AL445205, BC040909
      Related
      ENST00000412349.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      64094442..64113791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      63970220..63989553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials