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    FUS2 Fus2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855272, updated on 2-Nov-2024

    Summary

    Official Symbol
    FUS2
    Official Full Name
    Fus2p
    Primary source
    SGD:S000004845
    Locus tag
    YMR232W
    See related
    AllianceGenome:SGD:S000004845; FungiDB:YMR232W; VEuPathDB:YMR232W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cytogamy and karyogamy involved in conjugation with cellular fusion. Located in cytoplasm; mating projection tip; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See FUS2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (736926..738959)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tethering complex subunit PEP5 Neighboring gene Tri1p Neighboring gene RNA-DNA hybrid ribonuclease

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytogamy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actomyosin contractile ring contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of division septum assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell tip IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Fus2p
    NP_013959.1
    • Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      736926..738959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182739.1NP_013959.1  TPA: Fus2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W058, Q05023, Q05670
      UniProtKB/TrEMBL
      B3LMC1, C7GRB8, C8ZF97, N1P0K3
      Conserved Domains (1) summary
      cl02571
      Location:114301
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.