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    AFR1 Afr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851658, updated on 2-Nov-2024

    Summary

    Official Symbol
    AFR1
    Official Full Name
    Afr1p
    Primary source
    SGD:S000002492
    Locus tag
    YDR085C
    See related
    AllianceGenome:SGD:S000002492; FungiDB:YDR085C; VEuPathDB:YDR085C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable actin binding activity. Involved in several processes, including cell morphogenesis involved in conjugation with cellular fusion; mating; and protein localization to bud neck. Located in mating projection base and peroxisome. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See AFR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (614288..616150, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase Neighboring gene Tvp23p Neighboring gene translocon subunit SSS1 Neighboring gene Rrp1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mating IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to bud neck IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in septin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mating projection base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Afr1p
    NP_010370.1
    • Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      614288..616150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180393.1NP_010370.1  TPA: Afr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS72, P33304
      UniProtKB/TrEMBL
      B3LGI6, N1P4N5