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    Ccdc63 coiled-coil domain containing 63 [ Mus musculus (house mouse) ]

    Gene ID: 330188, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc63provided by MGI
    Official Full Name
    coiled-coil domain containing 63provided by MGI
    Primary source
    MGI:MGI:3607777
    See related
    Ensembl:ENSMUSG00000043036 AllianceGenome:MGI:3607777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921511C16Rik
    Summary
    Involved in spermatid development. Predicted to be active in axoneme. Orthologous to human CCDC63 (coiled-coil domain containing 63). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 46.0) See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc63 in Genome Data Viewer
    Location:
    5 F; 5 62.17 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122246115..122276143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122108052..122138080, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52785 Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC118568726 Neighboring gene predicted gene, 52786 Neighboring gene VISTA enhancer mm77 Neighboring gene STARR-seq mESC enhancer starr_14271 Neighboring gene STARR-positive B cell enhancer ABC_E3613 Neighboring gene myosin, light polypeptide 2, regulatory, cardiac, slow Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595403-122595586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595588-122595697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122634438-122634667 Neighboring gene STARR-seq mESC enhancer starr_14277 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene STARR-positive B cell enhancer ABC_E9650 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122685188-122685492 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Young SA, et al. Int J Mol Sci, 2015 Oct 16. PMID 26501274, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289809.1 → NP_001276738.1  coiled-coil domain-containing protein 63 isoform 1

      See identical proteins and their annotated locations for NP_001276738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK029513, AV276792, AV278877, AV279232, AV280582, AV281915, BB614558
      UniProtKB/TrEMBL
      A7YTZ6

    2. NM_001289811.1 → NP_001276740.1  coiled-coil domain-containing protein 63 isoform 3

      See identical proteins and their annotated locations for NP_001276740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, initiates translation at a downstrean start codon and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC140353, AK029513, AV278877, AV281915, BB614558
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6

    3. NM_001384197.1 → NP_001371126.1  coiled-coil domain-containing protein 63 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140353
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      UniProtKB/TrEMBL
      D3YUZ2
      Conserved Domains (1) summary
      TIGR02168
      Location:148 → 422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_001384198.1 → NP_001371127.1  coiled-coil domain-containing protein 63 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140353
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      Conserved Domains (1) summary
      TIGR02168
      Location:169 → 443
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. NM_001384199.1 → NP_001371128.1  coiled-coil domain-containing protein 63 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140353
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      UniProtKB/TrEMBL
      A0A0R4J0M8, D3YVN4
      Related
      ENSMUSP00000114311.3, ENSMUST00000132701.3
      Conserved Domains (1) summary
      TIGR02168
      Location:169 → 443
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. NM_001384200.1 → NP_001371129.1  coiled-coil domain-containing protein 63 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140353
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      Conserved Domains (1) summary
      TIGR02168
      Location:148 → 422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. NM_001384201.1 → NP_001371130.1  coiled-coil domain-containing protein 63 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140353
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      UniProtKB/TrEMBL
      D3YUZ2
      Related
      ENSMUSP00000114804.3, ENSMUST00000128101.9
      Conserved Domains (1) summary
      TIGR02168
      Location:148 → 422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. NM_183307.4 → NP_899130.1  coiled-coil domain-containing protein 63 isoform 2

      See identical proteins and their annotated locations for NP_899130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region and uses an alternate splice site in the 3' terminal exon. This results in novel 3' coding region and novel 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK029513, AV278877, AV281915
      Consensus CDS
      CCDS39253.1
      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6
      UniProtKB/TrEMBL
      A0A0R4J0M8, D3YVN4
      Related
      ENSMUSP00000050582.8, ENSMUST00000058960.14
      Conserved Domains (1) summary
      TIGR02168
      Location:169 → 443
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122246115..122276143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248224.3 → XP_011246526.1  coiled-coil domain-containing protein 63 isoform X1

      See identical proteins and their annotated locations for XP_011246526.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:72 → 442
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_011248228.3 → XP_011246530.1  coiled-coil domain-containing protein 63 isoform X2

      See identical proteins and their annotated locations for XP_011246530.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:51 → 421
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_011248225.2 → XP_011246527.1  coiled-coil domain-containing protein 63 isoform X1

      See identical proteins and their annotated locations for XP_011246527.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:72 → 442
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_011248227.3 → XP_011246529.1  coiled-coil domain-containing protein 63 isoform X2

      See identical proteins and their annotated locations for XP_011246529.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:51 → 421
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_011248229.3 → XP_011246531.1  coiled-coil domain-containing protein 63 isoform X3

      UniProtKB/Swiss-Prot
      Q0VF78, Q8CDV6

    6. XM_011248222.3 → XP_011246524.1  coiled-coil domain-containing protein 63 isoform X1

      See identical proteins and their annotated locations for XP_011246524.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:72 → 442
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_011248223.4 → XP_011246525.1  coiled-coil domain-containing protein 63 isoform X1

      See identical proteins and their annotated locations for XP_011246525.1

      UniProtKB/TrEMBL
      A7YTZ6
      Conserved Domains (1) summary
      COG1196
      Location:72 → 442
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006530389.5 → XP_006530452.1  coiled-coil domain-containing protein 63 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDV6.2 GenPept UniProtKB/Swiss-Prot:Q8CDV6

    Gene LinkOut

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