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    Rabggta Rab geranylgeranyl transferase, a subunit [ Mus musculus (house mouse) ]

    Gene ID: 56187, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rabggtaprovided by MGI
    Official Full Name
    Rab geranylgeranyl transferase, a subunitprovided by MGI
    Primary source
    MGI:MGI:1860443
    See related
    Ensembl:ENSMUSG00000040472 AllianceGenome:MGI:1860443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gm
    Summary
    Enables Rab geranylgeranyltransferase activity. Acts upstream of or within protein geranylgeranylation. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. Used to study Hermansky-Pudlak syndrome. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.8), liver adult (RPKM 17.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rabggta in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55953321..55959720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55715864..55722263, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene predicted gene, 25887 Neighboring gene STARR-seq mESC enhancer starr_36777 Neighboring gene transglutaminase 1, K polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E7317 Neighboring gene STARR-positive B cell enhancer ABC_E2425 Neighboring gene dehydrogenase/reductase 1 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Novak EK, et al. Blood, 1995 Apr 1. PMID 7703484
    2. Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. Swank RT, et al. Blood, 1993 May 15. PMID 8490171
    3. Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. Taylor A, et al. Small GTPases, 2011 May. PMID 21776414, Free PMC Article
    4. The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. Coxon FP, et al. Bone, 2011 Jul. PMID 21419243
    5. Increased incidence and analysis of emperipolesis in megakaryocytes of the mouse mutant gunmetal. McGarry MP, et al. Exp Mol Pathol, 1999 Aug. PMID 10486237

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Rab geranylgeranyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein geranylgeranylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of Rab-protein geranylgeranyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    geranylgeranyl transferase type-2 subunit alpha
    Names
    geranylgeranyl transferase type II subunit alpha
    gunmetal
    rab GG transferase alpha
    rab GGTase alpha
    rab geranylgeranyltransferase subunit alpha
    NP_001347316.1
    NP_001347317.1
    NP_062392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360387.1 → NP_001347316.1  geranylgeranyl transferase type-2 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      AK002625, CD776583, CX213914
      Consensus CDS
      CCDS36933.1
      UniProtKB/Swiss-Prot
      Q9JHK4, Q9JLX2
      UniProtKB/TrEMBL
      Q3UIH7
      Related
      ENSMUSP00000128668.2, ENSMUST00000163889.3
      Conserved Domains (5) summary
      COG4886
      Location:354 → 520
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      pfam14580
      Location:468 → 562
      LRR_9; Leucine-rich repeat
      cl27590
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat

    2. NM_001360388.1 → NP_001347317.1  geranylgeranyl transferase type-2 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      AF127656, BY150143, CD776583
      Consensus CDS
      CCDS36933.1
      UniProtKB/Swiss-Prot
      Q9JHK4, Q9JLX2
      UniProtKB/TrEMBL
      Q3UIH7
      Related
      ENSMUSP00000154725.2, ENSMUST00000227061.2
      Conserved Domains (5) summary
      COG4886
      Location:354 → 520
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      pfam14580
      Location:468 → 562
      LRR_9; Leucine-rich repeat
      cl27590
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat

    3. NM_019519.3 → NP_062392.1  geranylgeranyl transferase type-2 subunit alpha

      See identical proteins and their annotated locations for NP_062392.1

      Status: VALIDATED

      Source sequence(s)
      AF127658, CD776583
      Consensus CDS
      CCDS36933.1
      UniProtKB/Swiss-Prot
      Q9JHK4, Q9JLX2
      UniProtKB/TrEMBL
      Q3UIH7
      Related
      ENSMUSP00000133032.2, ENSMUST00000169237.8
      Conserved Domains (5) summary
      COG4886
      Location:354 → 520
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      pfam14580
      Location:468 → 562
      LRR_9; Leucine-rich repeat
      cl27590
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat

    RNA

    1. NR_153435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF127660, BY150143, CD776583
      Related
      ENSMUST00000228826.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55953321..55959720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHK4.1 GenPept UniProtKB/Swiss-Prot:Q9JHK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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