Coro1c coronin 1C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coro1cprovided by RGD
Official Full Name: coronin 1Cprovided by RGD
Primary source: RGD:1564490
See related: EnsemblRapid:ENSRNOG00000000697 AllianceGenome:RGD:1564490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564490
Summary: Predicted to enable actin filament binding activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of cell-substrate adhesion; regulation of cell migration; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within corpus callosum development and ventricular system development. Predicted to be located in several cellular components, including endosome membrane; lamellipodium; and lateral plasma membrane. Predicted to be part of flotillin complex. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 179.4), Heart (RPKM 108.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48373573..48445718)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42713024..42785179)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48481741..48554054)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Rat21 (e-PCR)
- UniSTS:118275

RH137525 (e-PCR)
- UniSTS:219613

BI278729 (e-PCR)
- UniSTS:244449

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corpus callosum development	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosome fission	ISO Inferred from Sequence Orthology more info
involved_in endosome membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of smooth muscle cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
NOT located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-1C

Names: coronin, actin binding protein 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109327.3 → NP_001102797.1 coronin-1C

See identical proteins and their annotated locations for NP_001102797.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6ANC4, A6J220, G3V624

Related

ENSRNOP00000000886.5, ENSRNOT00000000886.6

Conserved Domains (2) summary

sd00039
Location:36 → 78

7WD40; WD40 repeat [structural motif]

cl29593
Location:8 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...