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    Impa2 inositol monophosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Impa2provided by RGD
    Official Full Name
    inositol monophosphatase 2provided by RGD
    Primary source
    RGD:628692
    See related
    EnsemblRapid:ENSRNOG00000018516 AllianceGenome:RGD:628692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inositol monophosphate 1-phosphatase activity and protein homodimerization activity. Predicted to be involved in inositol metabolic process; response to lithium ion; and signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 67.4), Thymus (RPKM 46.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63104113..63135232)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (60834206..60867575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63016577..63050123)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene charged multivesicular body protein 1B Neighboring gene metallophosphoesterase 1 Neighboring gene uncharacterized LOC120098339 Neighboring gene uncharacterized LOC134483046 Neighboring gene cell death-inducing DFFA-like effector a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Yoon IS, et al. Mol Psychiatry, 2001 Nov. PMID 11673796
    2. Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Yoshikawa T, et al. Mol Psychiatry, 2001 Mar. PMID 11317223
    3. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. Yoshikawa T, et al. Mol Psychiatry, 1997 Sep. PMID 9322233
    4. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder. Sjøholt G, et al. Mol Psychiatry, 2004 Jun. PMID 14699425
    5. Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases. Shamir A, et al. Gene, 2001 Jun 27. PMID 11418250

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93085

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol monophosphatase 2
    Names
    IMP 2
    IMPase 2
    inositol (myo)-1(or 4)-monophosphatase 2
    inositol-1(or 4)-monophosphatase 2
    myo-inositol monophosphatase A2
    NP_757378.1
    XP_038952536.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172224.1 → NP_757378.1  inositol monophosphatase 2

      See identical proteins and their annotated locations for NP_757378.1

      Status: PROVISIONAL

      Source sequence(s)
      AY160191
      UniProtKB/Swiss-Prot
      Q8CIN7
      UniProtKB/TrEMBL
      A6IXU0, A6IXU1
      Related
      ENSRNOP00000025147.4, ENSRNOT00000025147.7
      Conserved Domains (1) summary
      cd01639
      Location:21 → 266
      IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63104113..63135232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096608.2 → XP_038952536.1  inositol monophosphatase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUN5
      Related
      ENSRNOP00000069164.2, ENSRNOT00000085655.3
      Conserved Domains (1) summary
      cd01639
      Location:28 → 259
      IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIN7.1 GenPept UniProtKB/Swiss-Prot:Q8CIN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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