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    Grtp1 growth hormone regulated TBC protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361180, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Grtp1provided by RGD
    Official Full Name
    growth hormone regulated TBC protein 1provided by RGD
    Primary source
    RGD:1309210
    See related
    EnsemblRapid:ENSRNOG00000071336 AllianceGenome:RGD:1309210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00052
    Summary
    Predicted to enable GTPase activator activity. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 205.4), Muscle (RPKM 140.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grtp1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83034931..83056589)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76332777..76356414)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81665533..81689525)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 beta, pseudogene 1 Neighboring gene uncharacterized LOC102548586 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene uncharacterized LOC134482532 Neighboring gene cullin 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116122

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    growth hormone-regulated TBC protein 1
    Names
    GH regulated TBC protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031813.2 → NP_001026983.1  growth hormone-regulated TBC protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001026983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC097985, CB315310
      UniProtKB/Swiss-Prot
      Q4QQU7
      UniProtKB/TrEMBL
      A0A8L2QWJ1
      Related
      ENSRNOP00000065337.2, ENSRNOT00000073240.5
      Conserved Domains (1) summary
      pfam00566
      Location:67 → 231
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. NM_001170477.2 → NP_001163948.1  growth hormone-regulated TBC protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001163948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWJ1, D4A2E4
      Related
      ENSRNOP00000026546.6, ENSRNOT00000026546.10
      Conserved Domains (1) summary
      smart00164
      Location:71 → 284
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      83034931..83056589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094683.2 → XP_038950611.1  growth hormone-regulated TBC protein 1 isoform X1

      Related
      ENSRNOP00000110009.1, ENSRNOT00000134093.1
      Conserved Domains (1) summary
      pfam00566
      Location:67 → 157
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_063275574.1 → XP_063131644.1  growth hormone-regulated TBC protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQU7.1 GenPept UniProtKB/Swiss-Prot:Q4QQU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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