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    Dync1i1 dynein cytoplasmic 1 intermediate chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29564, updated on 14-Nov-2024

    Summary

    Official Symbol
    Dync1i1provided by RGD
    Official Full Name
    dynein cytoplasmic 1 intermediate chain 1provided by RGD
    Primary source
    RGD:2512
    See related
    EnsemblRapid:ENSRNOG00000009700 AllianceGenome:RGD:2512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnci1; Dncic1; IC74-1A; IC74-1B
    Summary
    Enables microtubule binding activity and microtubule motor activity. Involved in vesicle transport along microtubule. Located in axon cytoplasm; perinuclear region of cytoplasm; and piccolo-bassoon transport vesicle. Part of cytoplasmic dynein complex. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 381.0) and Adrenal (RPKM 137.9) See more
    Orthologs
    NEW
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    Genomic context

    See Dync1i1 in Genome Data Viewer
    Location:
    4q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (34819313..35132647)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (33852597..34166159)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (30807755..31121097)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase 4 Neighboring gene ribosomal protein S29, pseudogene 20 Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 25 member 13 Neighboring gene protein LLP homolog pseudogene Neighboring gene ribosomal protein L31 like 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular transport of virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle transport along microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in piccolo-bassoon transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cytoplasmic dynein 1 intermediate chain 1
    Names
    DH IC-1
    Dnci 1
    cytoplasmic dynein intermediate chain 1
    dynein cytoplasmic 1 intermediate chain 1A
    dynein cytoplasmic 1 intermediate chain 1B
    dynein cytoplasmic 1 intermediate chain 1C
    dynein cytoplasmic 1 intermediate chain 1D
    dynein intermediate chain 1, cytosolic
    dynein, cytoplasmic, intermediate chain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019234.2NP_062107.2  cytoplasmic dynein 1 intermediate chain 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q63100
      UniProtKB/TrEMBL
      A6IDT9, G3V792
      Related
      ENSRNOP00000013184.5, ENSRNOT00000013184.6
      Conserved Domains (3) summary
      sd00039
      Location:344383
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:145171
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl29593
      Location:281604
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      34819313..35132647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236026.5XP_006236088.1  cytoplasmic dynein 1 intermediate chain 1 isoform X1

      See identical proteins and their annotated locations for XP_006236088.1

      UniProtKB/Swiss-Prot
      Q63100
      UniProtKB/TrEMBL
      A0A173DW29
      Related
      ENSRNOP00000080715.2, ENSRNOT00000106012.2
      Conserved Domains (4) summary
      COG2319
      Location:184596
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:128154
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:327366
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:264587
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017592509.3XP_017447998.1  cytoplasmic dynein 1 intermediate chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A173DW30, A6IDU1
      Related
      ENSRNOP00000085770.1, ENSRNOT00000117171.2
      Conserved Domains (4) summary
      COG2319
      Location:164576
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:108134
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:307346
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:244567
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...