Rab27b RAB27B, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rab27bprovided by RGD
Full Name: RAB27B, member RAS oncogene familyprovided by RGD
Primary source: RGD:620114
See related: EnsemblRapid:ENSRNOG00000012176 AllianceGenome:RGD:620114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in anterograde axonal protein transport; regulation of exocytosis; and synaptic vesicle endocytosis. Located in apical plasma membrane and zymogen granule membrane. Is active in synaptic vesicle membrane. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 111.5), Spleen (RPKM 81.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (65870230..66069597, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (63597554..63794124, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (68486006..68644595, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB27B regulates discoidal- and/or fusiform-shaped vesicle exocytosis in bladder umbrella cells.
Title: RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells.
The data of this study suggested that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/lysosomes to the cell membrane in oligodendrocytes.
Title: Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes.
cyt b(558) depends on clathrin for internalization, and in activated macrophages NADPH oxidase occupies a Rab27A/B-regulated secretory compartment
Title: NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.
Selective modulation of the GTP/GDP switch mechanism of Rab27b impairs synaptic vesicle recycling and suggests that Rab27b, in concert with Rab3a, is involved in synaptic vesicle exocytosis.
Title: Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.
Study shows that the Slp1/Rab27B/CRMP-2 complex directly links TrkB to Kinesin-1, and that this association is required for the anterograde transport of TrkB-containing vesicles in axons.
Title: Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
the Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells
Title: The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
These results demonstrate that Rab27b is present on ZGs and plays an important role in regulating acinar exocytosis.
Title: Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-27B

NP_445911.1

EC 3.6.5.2

XP_006254992.1

EC 3.6.5.2

XP_017456535.1

EC 3.6.5.2

XP_038953121.1

EC 3.6.5.2

XP_038953122.1

EC 3.6.5.2

XP_038953123.1

EC 3.6.5.2

XP_038953127.1

EC 3.6.5.2

XP_063133705.1

EC 3.6.5.2

XP_063133706.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053459.1 → NP_445911.1 ras-related protein Rab-27B

See identical proteins and their annotated locations for NP_445911.1

Status: PROVISIONAL

Source sequence(s)

AF325693

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5

Related

ENSRNOP00000095120.1, ENSRNOT00000106463.2

Conserved Domains (1) summary

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

65870230..66069597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097195.2 → XP_038953123.1 ras-related protein Rab-27B isoform X1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5

Conserved Domains (1) summary

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
XM_063277636.1 → XP_063133706.1 ras-related protein Rab-27B isoform X1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5
XM_063277635.1 → XP_063133705.1 ras-related protein Rab-27B isoform X1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5
XM_006254930.5 → XP_006254992.1 ras-related protein Rab-27B isoform X1

See identical proteins and their annotated locations for XP_006254992.1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5

Conserved Domains (1) summary

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
XM_039097193.2 → XP_038953121.1 ras-related protein Rab-27B isoform X1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5

Conserved Domains (1) summary

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
XM_039097194.2 → XP_038953122.1 ras-related protein Rab-27B isoform X1

UniProtKB/Swiss-Prot

Q99P74

UniProtKB/TrEMBL

A6IXZ5

Conserved Domains (1) summary

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
XM_017601046.3 → XP_017456535.1 ras-related protein Rab-27B isoform X2

UniProtKB/TrEMBL

A0A8L2Q7R9

Related

ENSRNOP00000016369.2, ENSRNOT00000016369.5
XM_039097199.2 → XP_038953127.1 ras-related protein Rab-27B isoform X3