Wwc3 WWC family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wwc3provided by RGD
Official Full Name: WWC family member 3provided by RGD
Primary source: RGD:1560666
See related: EnsemblRapid:ENSRNOG00000024250 AllianceGenome:RGD:1560666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560666
Summary: Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC3 (WWC family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 118.0), Lung (RPKM 115.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: Xq13

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (27146018..27263446)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (23584204..23701864)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (24872496..24988671)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WWC3 is able to interact with LATS1 to upregulate the Hippo-YAP signaling pathway and suppress the proliferation and migration of VSMCs.
Title: WWC3 inhibits intimal proliferation following vascular injury via the Hippo signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130302 (e-PCR)
- UniSTS:213588

DXMco1 (e-PCR)
- UniSTS:239597

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein WWC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.