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    Asb1 ankyrin repeat and SOCS box-containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb1provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 1provided by RGD
    Primary source
    RGD:1310760
    See related
    EnsemblRapid:ENSRNOG00000020322 AllianceGenome:RGD:1310760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 105.8), Spleen (RPKM 91.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb1 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99566852..99588321)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (92120332..92140790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98668231..98689471)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480413 Neighboring gene TRAF3 interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480414 Neighboring gene uncharacterized LOC102548291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    2. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male genitalia development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 1
    Names
    ankyrin repeat and SOCS box-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108232.2 → NP_001101702.1  ankyrin repeat and SOCS box protein 1

      See identical proteins and their annotated locations for NP_001101702.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168978
      UniProtKB/TrEMBL
      B5DF97, F7F1S8
      Related
      ENSRNOP00000027528.7, ENSRNOT00000027528.7
      Conserved Domains (4) summary
      PHA02875
      Location:80 → 266
      PHA02875; ankyrin repeat protein; Provisional
      cd03720
      Location:294 → 335
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:79 → 108
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:82 → 173
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99566852..99588321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083762.2 → XP_038939690.1  ankyrin repeat and SOCS box protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYZ6, F7F1S8
      Related
      ENSRNOP00000084202.1, ENSRNOT00000094785.2
      Conserved Domains (5) summary
      PHA02875
      Location:84 → 270
      PHA02875; ankyrin repeat protein; Provisional
      cd03720
      Location:298 → 339
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:83 → 112
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:86 → 177
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:26 → 112
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039083763.2 → XP_038939691.1  ankyrin repeat and SOCS box protein 1 isoform X3

      UniProtKB/TrEMBL
      F7F1S8
      Conserved Domains (5) summary
      PHA02875
      Location:76 → 262
      PHA02875; ankyrin repeat protein; Provisional
      cd03720
      Location:290 → 331
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:75 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:78 → 169
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:18 → 104
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_063267322.1 → XP_063123392.1  ankyrin repeat and SOCS box protein 1 isoform X6

      UniProtKB/TrEMBL
      A6JQT1
      Related
      ENSRNOP00000109847.1, ENSRNOT00000173875.1

    4. XM_006245410.5 → XP_006245472.1  ankyrin repeat and SOCS box protein 1 isoform X4

      UniProtKB/TrEMBL
      F7F1S8
      Conserved Domains (5) summary
      cd00204
      Location:72 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:287 → 328
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:75 → 166
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:30 → 91
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:72 → 101
      ANK; ANK repeat [structural motif]

    5. XM_063267323.1 → XP_063123393.1  ankyrin repeat and SOCS box protein 1 isoform X7

    6. XM_063267324.1 → XP_063123394.1  ankyrin repeat and SOCS box protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AUV4

    7. XM_006245409.5 → XP_006245471.1  ankyrin repeat and SOCS box protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006245471.1

      UniProtKB/TrEMBL
      A6JQT2, F7F1S8
      Related
      ENSRNOP00000097757.2, ENSRNOT00000118191.2
      Conserved Domains (5) summary
      cd00204
      Location:76 → 209
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:291 → 332
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:79 → 170
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:34 → 95
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:76 → 105
      ANK; ANK repeat [structural motif]

    8. XM_063267321.1 → XP_063123391.1  ankyrin repeat and SOCS box protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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