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    Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300862, updated on 27-Nov-2024

    Summary

    Official Symbol
    Irak1bp1provided by RGD
    Official Full Name
    interleukin-1 receptor-associated kinase 1 binding protein 1provided by RGD
    Primary source
    RGD:1305012
    See related
    EnsemblRapid:ENSRNOG00000008984 AllianceGenome:RGD:1305012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Orthologous to human IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 97.0), Testes (RPKM 82.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Irak1bp1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (92608468..92628377)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (83731512..83748289)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (90343307..90360085)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 4 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene uncharacterized LOC108351752

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277283.1NP_001264212.1  interleukin-1 receptor-associated kinase 1-binding protein 1

      See identical proteins and their annotated locations for NP_001264212.1

      Status: VALIDATED

      Source sequence(s)
      BC159433, JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I1P8, B0K033, D3ZBV8
      Related
      ENSRNOP00000079440.2, ENSRNOT00000116444.2
      Conserved Domains (1) summary
      pfam04402
      Location:55196
      SIMPL; Protein of unknown function (DUF541)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      92608468..92628377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265187.1XP_063121257.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

    RNA

    1. XR_010053950.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106843.1: Suppressed sequence

      Description
      NM_001106843.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.