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    Camsap3 calmodulin regulated spectrin-associated protein family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689074, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Camsap3provided by RGD
    Official Full Name
    calmodulin regulated spectrin-associated protein family, member 3provided by RGD
    Primary source
    RGD:1597412
    See related
    EnsemblRapid:ENSRNOG00000000986 AllianceGenome:RGD:1597412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307246
    Summary
    Predicted to enable actin filament binding activity and microtubule minus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; regulation of microtubule polymerization or depolymerization; and zonula adherens maintenance. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytoskeleton; motile cilium; and zonula adherens. Predicted to colocalize with microtubule minus-end. Orthologous to human CAMSAP3 (calmodulin regulated spectrin associated protein family member 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 39.8), Brain (RPKM 24.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camsap3 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6440959..6464582)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1643062..1666685)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2133935..2157403)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mucolipin TRP cation channel 1 Neighboring gene uncharacterized LOC120095868 Neighboring gene patatin-like phospholipase domain containing 6 Neighboring gene XPA binding protein 2 Neighboring gene PET100 cytochrome c oxidase chaperone Neighboring gene Purkinje cell protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A microtubule-organizing center directing intracellular transport in the early mouse embryo. Zenker J, et al. Science, 2017 Sep 1. PMID 28860385
    2. CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells. Wang J, et al. J Genet Genomics, 2017 Jan 20. PMID 28089391
    3. Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7. Noordstra I, et al. J Cell Sci, 2016 Nov 15. PMID 27802168
    4. The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics. Ning W, et al. Dev Cell, 2016 Oct 10. PMID 27693509
    5. CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells. Toya M, et al. Proc Natl Acad Sci U S A, 2016 Jan 12. PMID 26715742, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule minus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of organelle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zonula adherens maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zonula adherens maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule minus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in zonula adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in zonula adherens ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-regulated spectrin-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144840.1 → NP_001138312.1  calmodulin-regulated spectrin-associated protein 3

      Status: PROVISIONAL

      Source sequence(s)
      CH474084
      UniProtKB/TrEMBL
      A6KQ12, D3ZXQ2
      Related
      ENSRNOP00000001305.6, ENSRNOT00000001305.9
      Conserved Domains (3) summary
      pfam08683
      Location:1130 → 1248
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:230 → 312
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:604 → 661
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      6440959..6464582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598455.3 → XP_017453944.1  calmodulin-regulated spectrin-associated protein 3 isoform X6

    2. XM_006248776.5 → XP_006248838.1  calmodulin-regulated spectrin-associated protein 3 isoform X1

      Related
      ENSRNOP00000092580.2, ENSRNOT00000101379.2
      Conserved Domains (3) summary
      pfam08683
      Location:1142 → 1260
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:241 → 323
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:616 → 673
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    3. XM_063271665.1 → XP_063127735.1  calmodulin-regulated spectrin-associated protein 3 isoform X10

    4. XM_039089766.2 → XP_038945694.1  calmodulin-regulated spectrin-associated protein 3 isoform X3

      Conserved Domains (3) summary
      pfam11971
      Location:230 → 312
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1131 → 1249
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:605 → 662
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    5. XM_006248779.5 → XP_006248841.1  calmodulin-regulated spectrin-associated protein 3 isoform X4

      Related
      ENSRNOP00000084006.2, ENSRNOT00000096347.2
      Conserved Domains (3) summary
      pfam08683
      Location:1126 → 1244
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:225 → 307
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:600 → 657
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    6. XM_063271666.1 → XP_063127736.1  calmodulin-regulated spectrin-associated protein 3 isoform X11

    7. XM_006248777.5 → XP_006248839.1  calmodulin-regulated spectrin-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHT4
      Conserved Domains (3) summary
      pfam08683
      Location:1141 → 1259
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:241 → 323
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:615 → 672
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    8. XM_006248781.5 → XP_006248843.1  calmodulin-regulated spectrin-associated protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AFS8
      Related
      ENSRNOP00000087038.1, ENSRNOT00000108516.2
      Conserved Domains (3) summary
      pfam08683
      Location:1115 → 1233
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:214 → 296
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:589 → 646
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    9. XM_008769001.4 → XP_008767223.1  calmodulin-regulated spectrin-associated protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G9R5
      Conserved Domains (3) summary
      pfam08683
      Location:1125 → 1243
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:225 → 307
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:599 → 656
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    10. XM_006248782.5 → XP_006248844.1  calmodulin-regulated spectrin-associated protein 3 isoform X8

      Conserved Domains (3) summary
      pfam08683
      Location:1114 → 1232
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:214 → 296
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:588 → 645
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    11. XM_017598456.3 → XP_017453945.1  calmodulin-regulated spectrin-associated protein 3 isoform X9

    12. XM_063271667.1 → XP_063127737.1  calmodulin-regulated spectrin-associated protein 3 isoform X12

    13. XM_063271668.1 → XP_063127738.1  calmodulin-regulated spectrin-associated protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A0G2K5C0
      Related
      ENSRNOP00000073369.1, ENSRNOT00000084906.3
    Nucleotide Protein Strain
    Heading Accession and Version

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