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    Maf1 MAF1 homolog, negative regulator of RNA polymerase III [ Mus musculus (house mouse) ]

    Gene ID: 68877, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Maf1provided by MGI
    Official Full Name
    MAF1 homolog, negative regulator of RNA polymerase IIIprovided by MGI
    Primary source
    MGI:MGI:1916127
    See related
    Ensembl:ENSMUSG00000022553 AllianceGenome:MGI:1916127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110068E11Rik
    Summary
    Predicted to enable GABA receptor binding activity; RNA polymerase III cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Located in nucleus. Is expressed in adrenal gland; liver; retina; and thymus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 55.3), ovary adult (RPKM 45.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Maf1 in Genome Data Viewer
    Location:
    15 D3; 15 35.75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76235494..76238578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76351294..76354378)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cytochrome c-1 Neighboring gene SHANK-associated RH domain interacting protein Neighboring gene WD repeat domain 97 Neighboring gene STARR-seq mESC enhancer starr_39052 Neighboring gene STARR-positive B cell enhancer ABC_E11592 Neighboring gene HGH1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2. Sun Y, et al. Theranostics, 2019. PMID 31695767, Free PMC Article
    2. Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease. Han Y, et al. Brain, 2024 Jun 3. PMID 38226680, Free PMC Article
    3. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Bonhoure N, et al. Genes Dev, 2015 May 1. PMID 25934505, Free PMC Article
    4. Metabolic programming a lean phenotype by deregulation of RNA polymerase III. Willis IM, et al. Proc Natl Acad Sci U S A, 2018 Nov 27. PMID 30429315, Free PMC Article
    5. MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse. Bonhoure N, et al. Sci Rep, 2020 Jul 20. PMID 32686713, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease.
      Title: Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease.
    2. Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke.
      Title: Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke.
    3. MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass.
      Title: MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass.
    4. Maf1 mitigates sevoflurane-induced microglial inflammatory damage and attenuates microglia-mediated neurotoxicity in HT-22 cells by activating the AMPK/Nrf2 signaling.
      Title: Maf1 mitigates sevoflurane-induced microglial inflammatory damage and attenuates microglia-mediated neurotoxicity in HT-22 cells by activating the AMPK/Nrf2 signaling.
    5. Maf1 regulates axonal regeneration of retinal ganglion cells after injury.
      Title: Maf1 regulates axonal regeneration of retinal ganglion cells after injury.
    6. Maf1 regulates dendritic morphogenesis and influences learning and memory.
      Title: Maf1 regulates dendritic morphogenesis and influences learning and memory.
    7. Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2.
      Title: Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2.
    8. The studies reveal an important and unexpected function for RNA pol III-mediated transcription and Maf1 in mesoderm induction and adipocyte differentiation.
      Title: Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation.
    9. can act as a transcriptional activator for PTEN, which is important for MAF1's tumor-suppressor function
      Title: MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.
    10. novel role for Maf1 in suppressing both lipid biogenesis and tumor formation; Maf1 elicits these biological responses through its ability to repress genes that that synthesize lipids and regulate biosynthetic capacity.
      Title: Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase III core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III type 1 promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III type 1 promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase III type 2 promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III type 2 promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    repressor of RNA polymerase III transcription MAF1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164607.1 → NP_001158079.1  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_001158079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK004406, BY118992, BY595681, CK619143
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000125387.2, ENSMUST00000161527.8
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 202
      Maf1; Maf1 regulator

    2. NM_001164608.1 → NP_001158080.1  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_001158080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AK042913, BY118992
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000124893.2, ENSMUST00000160853.8
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 202
      Maf1; Maf1 regulator

    3. NM_026859.3 → NP_081135.3  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_081135.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AK004406, AK042913, BB250147, BY118992
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000023212.9, ENSMUST00000023212.15
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 202
      Maf1; Maf1 regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76235494..76238578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0U6.1 GenPept UniProtKB/Swiss-Prot:Q9D0U6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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