Prkcd protein kinase C, delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkcdprovided by MGI
Official Full Name: protein kinase C, deltaprovided by MGI
Primary source: MGI:MGI:97598
See related: Ensembl:ENSMUSG00000021948 AllianceGenome:MGI:97598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pkcd; PKC[d]; PKCdelta; D14Ertd420e
Summary: Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity and insulin receptor substrate binding activity. Involved in several processes, including negative regulation of cellular component organization; negative regulation of insulin receptor signaling pathway; and negative regulation of platelet aggregation. Acts upstream of or within B cell proliferation; immunoglobulin mediated immune response; and positive regulation of apoptotic signaling pathway. Located in several cellular components, including cell-cell junction; cytoplasm; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 37.2), adrenal adult (RPKM 35.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 18.82 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (30317310..30348637, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (30595353..30626414, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis.
Title: Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
Title: Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
Loss of PKCdelta/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.
Title: Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.
The metabolomics of a protein kinase C delta (PKCdelta) knock-out mouse model.
Title: The metabolomics of a protein kinase C delta (PKCδ) knock-out mouse model.
Inhibition of PKC-delta reduce rhabdomyolysis-induced acute kidney injury.
Title: Inhibition of PKC-δ reduce rhabdomyolysis-induced acute kidney injury.
PKCdelta-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety.
Title: PKCδ-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety.
SMS2 deficiency impairs PKCdelta-regulated B cell tolerance in the germinal center.
Title: SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.
Protein kinase Cdelta is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria.
Title: Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria.
TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) delta/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice.
Title: TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice.
PKCdelta deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCdelta knockout mice.
Title: PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (251)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (8) 1 citation
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224276 (e-PCR)
- UniSTS:224276

NoName (e-PCR)
- UniSTS:548154

Prkcd (e-PCR), detects polymorphism
- UniSTS:144196

AI385711 (e-PCR)
- UniSTS:180622

D14Ertd420e (e-PCR), detects polymorphism
- UniSTS:167132

D16Mgh7 (e-PCR)
- UniSTS:239335

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables TIR domain binding	ISO Inferred from Sequence Orthology more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucosylceramide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glucosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sphingomyelin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sphingomyelin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in termination of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in termination of signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endolysosome	ISO Inferred from Sequence Orthology more info
located_in endolysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C delta type

Names: nPKC-delta; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; tyrosine-protein kinase PRKCD

NP_001297611.1

EC 2.7.10.2

EC 2.7.11.13

NP_001411429.1

EC 2.7.10.2

EC 2.7.11.13

NP_035233.1

EC 2.7.10.2

EC 2.7.11.13

XP_006518758.1

EC 2.7.10.2

EC 2.7.11.13

XP_006518760.1

EC 2.7.10.2

EC 2.7.11.13

XP_006518761.1

EC 2.7.10.2

EC 2.7.11.13

XP_017171407.1

EC 2.7.10.2

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310682.1 → NP_001297611.1 protein kinase C delta type isoform 1

See identical proteins and their annotated locations for NP_001297611.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA616214, AC154646, AI385711, AK168768, AW122017, BY750197, CF170573

Consensus CDS

CCDS79285.1

UniProtKB/TrEMBL

Q3UNG2

Related

ENSMUSP00000022521.7, ENSMUST00000022521.13

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:377 → 692

PKc_like; Protein Kinases, catalytic domain
NM_001424500.1 → NP_001411429.1 protein kinase C delta type isoform 2

Status: VALIDATED

Source sequence(s)

AC154646

UniProtKB/Swiss-Prot

P28867, Q91V85, Q9Z333

UniProtKB/TrEMBL

Q53YN4
NM_011103.4 → NP_035233.1 protein kinase C delta type isoform 2

See identical proteins and their annotated locations for NP_035233.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.

Source sequence(s)

AC154646

Consensus CDS

CCDS26895.1

UniProtKB/Swiss-Prot

P28867, Q91V85, Q9Z333

UniProtKB/TrEMBL

Q3UNG2, Q53YN4

Related

ENSMUSP00000107829.4, ENSMUST00000112210.11

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:351 → 666

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

30317310..30348637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518695.2 → XP_006518758.1 protein kinase C delta type isoform X1

See identical proteins and their annotated locations for XP_006518758.1

UniProtKB/TrEMBL

Q3UNG2

Related

ENSMUSP00000107830.3, ENSMUST00000112211.9

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:377 → 692

PKc_like; Protein Kinases, catalytic domain
XM_017315918.3 → XP_017171407.1 protein kinase C delta type isoform X1

UniProtKB/TrEMBL

Q3UNG2

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:377 → 692

PKc_like; Protein Kinases, catalytic domain
XM_006518698.5 → XP_006518761.1 protein kinase C delta type isoform X4

UniProtKB/TrEMBL

Q3UNG2

Related

ENSMUSP00000107822.2, ENSMUST00000112203.2

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:351 → 624

PKc_like; Protein Kinases, catalytic domain
XM_006518697.4 → XP_006518760.1 protein kinase C delta type isoform X2

UniProtKB/TrEMBL

Q3UNG2

Related

ENSMUSP00000107821.2, ENSMUST00000112202.8

Conserved Domains (2) summary

pfam00130
Location:231 → 281

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:377 → 650

PKc_like; Protein Kinases, catalytic domain