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    Ints1 integrator complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 68510, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ints1provided by MGI
    Official Full Name
    integrator complex subunit 1provided by MGI
    Primary source
    MGI:MGI:1915760
    See related
    Ensembl:ENSMUSG00000029547 AllianceGenome:MGI:1915760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110015K06Rik
    Summary
    Acts upstream of or within several processes, including U2 snRNA 3'-end processing; inner cell mass cell proliferation; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in nucleus. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 35.7), adrenal adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ints1 in Genome Data Viewer
    Location:
    5 G2; 5 78.8 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139737037..139761455, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139751282..139775702, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46926 Neighboring gene STARR-seq mESC enhancer starr_14696 Neighboring gene MICAL-like 2 Neighboring gene STARR-seq mESC enhancer starr_14697 Neighboring gene STARR-positive B cell enhancer ABC_E8087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene microRNA 7037 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene transmembrane protein 184a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1440

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrator complex subunit 1
    Names
    int1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026748.3NP_081024.4  integrator complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AC167333
      Consensus CDS
      CCDS57399.1
      UniProtKB/Swiss-Prot
      Q0KK58, Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7
      UniProtKB/TrEMBL
      A0A0G2JDG8, K3W4P2
      Related
      ENSMUSP00000143789.3, ENSMUST00000200393.5
      Conserved Domains (1) summary
      pfam12432
      Location:352432
      DUF3677; Protein of unknown function (DUF3677)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139737037..139761455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504729.5XP_006504792.1  integrator complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JH17
      Related
      ENSMUSP00000072406.7, ENSMUST00000072607.9
      Conserved Domains (1) summary
      pfam12432
      Location:377457
      DUF3677; Protein of unknown function (DUF3677)
    2. XM_006504728.5XP_006504791.1  integrator complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JH17
      Conserved Domains (1) summary
      pfam12432
      Location:377457
      DUF3677; Protein of unknown function (DUF3677)
    3. XM_006504727.5XP_006504790.1  integrator complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JH17
      Conserved Domains (1) summary
      pfam12432
      Location:379459
      DUF3677; Protein of unknown function (DUF3677)

    RNA

    1. XR_003955703.2 RNA Sequence

    2. XR_003955704.2 RNA Sequence